17-GMP-APA-GA

17-GMP-APA-GA Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.

• Verwenden

  17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates.

• Einzelnachweise

  1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460 2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786 3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573

17-GMP-APA-GA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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