(R)-Dimethindene Maleate

(R)-Dimethindene Maleate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  (R)-Dimethindene Maleate is a subtype-selective mAChR M2 antagonist and histamine H1 receptor antagonist.

• in vivo

  (R)-(+)-Dimethindene maleate (10 mL/kg; i.g.; once) shows antihistaminic activity with an ED₅₀ of 2.73 mg/kg in pigs^[1].

  Animal Model:	Male guinea-pigs[1]
  Dosage:	10 mL/kg
  Administration:	Oral gavage, once
  Result:	The ED50-value for a protection from a fatal histamine shock was calculated as 2.73 mg/kg when administered orally 1 h before the injection of histamine. The calculated oral anti-anaphylactic ED50-value was found to be >31.6mg/kg. The oral LD50-values was found to be 988 mg/kg.

• IC 50

  H₁ Receptor: 7.7 (pA2)

(R)-Dimethindene Maleate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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