(+)-Fenfluramine hydrochloride Struktur

(S)-N-Ethyl-α-methyl-m-(trifluormethyl)phenethylaminhydrochlorid

Bezeichnung:(S)-N-Ethyl-α-methyl-m-(trifluormethyl)phenethylaminhydrochlorid

CAS-Nr3239-45-0

Englisch Name:(+)-Fenfluramine hydrochloride

CBNumberCB2879459

SummenformelC12H16F3N.ClH

Molgewicht267.72

MOL-Datei3239-45-0.mol

Synonyma

(S)-N-Ethyl-α-methyl-m-(trifluormethyl)phenethylaminhydrochlorid

(S)-N-Ethyl-α-methyl-m-(trifluormethyl)phenethylaminhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	159-163°C
storage temp.	Desiccate at RT
Löslichkeit	H2O: soluble10mg/mL
Aggregatzustand	powder
Farbe	white to off-white

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	22-36/37/39-45
RIDADR	UN 2811
WGK Germany	3
RTECS-Nr.	SH6824000
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

(+)-Fenfluramine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Redux, having been already launched in Europe, was marketed in Canada and the US for obesity. The (+)-isomer of fenfluramine is obtained by resolution using d-camphoric acid and ultimate conversion to the HCl salt. The levo-isomer has significant effects on dopaminerigic neurotransmission, while the dextro-isomer has a greater anorectic effect because it is more selective on serotonin as a 5-HT agonist with no dopaminergic or noradenergic activity. Redux inhibits the presynaptic release of serotonin, is a reuptake inhibitor, a 5-HT_1B, receptor agonist, and a postsynaptic 5-HT_2C receptor agonist . A dietary reduction in fat intake was thought to proceed via a CCK A-type receptor agonist activity. Due to the side effects of primary pulmonary hypertension, brain serotonin neurotoxicity and valvular heart disease, Redux was withdrawn world wide.
Chemische Eigenschaften
White Crystalline Powder
Originator
Servier (France)
Verwenden
Controlled substance. Anorexic
Definition
ChEBI: The hydrochloride salt of (S)-fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike the racemate it does not possess catecholamine agonist activity. It was formerly given by mouth in the tre tment of obesity, but, like the racemate, was withdrawn wolrdwide following reports of valvular heart defects.
Trademarks
Redux (Interneuron).
Biologische Aktivität
Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.
Biochem/physiol Actions
(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.
Lager
Desiccate at RT

(S)-N-Ethyl-α-methyl-m-(trifluormethyl)phenethylaminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3239-45-0, (+)-Fenfluramine hydrochloride Verwandte Suche:

Send Inquriy