3-(4-Hydroxy-3,5-diiodphenyl)-2-phenylpropionsure

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P321：Besondere Behandlung

  P330：Mund ausspülen.

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P362：Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

  P391：Verschüttete Mengen aufnehmen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Pheniodol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Priodax,Schering,US,1943

• Definition

  ChEBI: Pheniodol sodium is a stilbenoid.

• Manufacturing Process

  Dextro-β-(4-hydroxyphenyl)-α-phenylpropionic acid (24 g) was dissolved in 630 ml of water containing 8.0 g of sodium hydroxide, and, with good stirring at 25°C, 51 g of iodine and 51 g of potassium iodide dissolved in 240 ml of water was added dropwise over a period of 30 minutes. During this period another 8 g of sodium hydroxide dissolved in 60 ml of water was added in order to keep the reaction mixture alkaline to phenolphthalein. Stirring was continued for 15 minutes longer. The resulting solution was made acid to Congo red with concentrated hydrochloric acid, and about 5 g of sodium bisulfite was added to partially decolorize the resulting slurry. The solid was collected by filtration and washed well with water.
  The crude iodinated acid was then dissolved in 500 ml of 95% alcohol, 10 g of dimethylaminoethanol was added, the solution was decolorized with activated charcoal and filtered at 70°C. After keeping the filtrate for several hours at 5°C. the heavy crystalline precipitate which formed was collected by filtration and washed with acetone. The mother liquors were concentrated to 150 ml and cooled to give a second crop which was further purified by recrystallization from 50 ml of 95% alcohol. In this way a total of 36.0 g of dimethylaminoethanol salt of dextro-β-(3,5-diiodo-4-hydroxy)-α- phenylpropionic acid, MP 151° to 153°C, was obtained. The melting point of the dimethylaminoethanol salt of unresolved β-(3,5-diiodo-4-hydroxy)-α- phenylpropionic acid was 142° to 144°C.
  The pure dimethylaminoethanol salt was dissolved in 400 ml of 50% acetic acid at 90°C and then cooled to 5°C. The solid which precipitated wascollected by filtration, washed with water, cold 50% acetic acid and finally with low-boiling petroleum ether. After drying in vacuo there was obtained 24 g of hydrated dextro-β-(3,5-diiodo-4-hydroxy)-α-phenylpropionic acid, MP 80° to 85°C.

• Trademarks

  Priodax (Schering).

• Therapeutic Function

  Diagnostic aid (radiopaque medium)

• Sicherheitsprofil

  Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of Ií.

Pheniodol Upstream-Materialien And Downstream Produkte

3-(4-Hydroxy-3,5-diiodphenyl)-2-phenylpropionsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(8)Suppliers

577-91-3, Pheniodol Verwandte Suche: