H-PRO-LEU-GLY-NH2 Struktur

L-Prolyl-L-leucylglycinamid

Bezeichnung:L-Prolyl-L-leucylglycinamid

CAS-Nr2002-44-0

Englisch Name:H-PRO-LEU-GLY-NH2

CBNumberCB2779319

SummenformelC13H24N4O3

Molgewicht284.35

MOL-Datei2002-44-0.mol

Synonyma

L-Prolyl-L-leucylglycinamid

L-Prolyl-L-leucylglycinamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	122-123 °C(Solv: water (7732-18-5))
Siedepunkt	626.2±55.0 °C(Predicted)
Dichte	1.147±0.06 g/cm3(Predicted)
storage temp.	-15°C
Löslichkeit	≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O
pka	14.10±0.20(Predicted)
Aggregatzustand	Lyophilized powder
Wasserlöslichkeit	Soluble in water.
Sequenz	H-Pro-Leu-Gly-NH2

H-PRO-LEU-GLY-NH2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
L-Prolyl-L-leucylglycinamide is shown to be effective in treating human depression with greater efficacy and faster onset of action than traditional anti-depressants.Also, it is used in the synthesis of novel analogs to be tested for their ability to enhance the binding of [3H]-N-propylnorapomorphine to short isoform of human dopamine D2 receptors.
Definition
ChEBI: Melanostatin is an oligopeptide.
Biologische Aktivität
melanocyte stimulating hormone release inhibiting factor,(c13h24n4o3), a tri-peptide with the sequence h2n-pro-leu-gly-amide, mw= 284.35. melanocyte-inhibiting factor (also known as pro-leu-gly-nh2, melanostatin, msh release-inhibiting hormone or mif-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body(1). mif-1 produces multiple effects, both blocking the effects of opioid receptor activation(2), while at the same time acting as a positive allosteric modulator of the d2 and d4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-msh, and potentiating melatonin activity(3). mif-1 is unusually resistant to metabolism in the bloodstream, and crosses the blood–brain barrier easily, though it is poorly active orally and is usually injected.figure1 formula of melanocyte stimulating hormone release inhibiting factor
Lager
-20°C (desiccate)
Einzelnachweise
1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.

L-Prolyl-L-leucylglycinamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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