(R)-(+)-2-Methyl-2-propanesulfinamide

Bezeichnung:(R)-(+)-2-Methyl-2-propanesulfinamide

CAS-Nr196929-78-9

Englisch Name:(R)-(+)-2-Methyl-2-propanesulfinamide

CBNumberCB2765464

SummenformelC4H11NOS

Molgewicht121.2

MOL-Datei196929-78-9.mol

(R)-(+)-2-Methyl-2-propanesulfinamide physikalisch-chemischer Eigenschaften

Schmelzpunkt	103-107 °C(lit.)
Siedepunkt	220.0±23.0 °C(Predicted)
alpha	4 º (c=1, CHCl3 + amylenes)
Dichte	0.903 g/mL at 25 °C
Brechungsindex	4 ° (C=1, CHCl3)
Flammpunkt	-17℃
storage temp.	2-8°C
Löslichkeit	Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.
Aggregatzustand	Powder
pka	10.11±0.50(Predicted)
Farbe	White, light pink, light yellow to brown
Optische Aktivität	[α]22/D +1.0°, c = 0.5% in chloroform
Stabilität	store cold
InChIKey	CESUXLKAADQNTB-SSDOTTSWSA-N
CAS Datenbank	196929-78-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn,F
R-Sätze:	11-19-36/37-40-36/37/38
S-Sätze:	22-24/25-36/37-26-16-36/37/39
RIDADR	UN 2056 3 / PGII
WGK Germany	3
Hazard Note	Irritant/Keep Cold
TSCA	No
HS Code	29309090

Gefahreninformationscode (GHS)

(R)-(+)-2-Methyl-2-propanesulfinamide Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
(R)-(+)-2-Methyl-2-propanesulfinamide is white to light yellow crystal powde
Verwenden
suzuki reaction, useful reagent for synthesizing chiral amines.
Verwenden
Chiral ligand used in pharmaceutical compositions
Verwenden
(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.
synthetische
Acetic acid (70 g), R-tert-butylsulfinylhydrazine (42 g), zinc powder (60.5 g) and dichloromethane (150 mL) were added to the reaction flask. The temperature was slowly heated to 35-42 °C . After 16 hours, the filtrate was poured into 70 mL water. Dichloromethane (75 g×5) was added for extraction. Collected the organic phase, added 48% NaOH to adjust ρΗ (7-8). Then added NaCl, the layers were separated and the organic phase was washed with 15 g saturated aqueous solution of sodium chloride. The solution was dried over magnesium sulfate. After filterED, filtrate was concentrated under reduced pressure at 25-30 °C until no slipping. N-heptane was replaced, 28 g mixed solvent of N-heptane and toluene (N-heptane: toluene = 6:1) were added to perform beating at low temperature, filtered to obtain (R)-(+)-2-Methyl-2-propanesulfinamide. Yield=83%
Einzelnachweise
[1] Qian X, et al. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist. Tetrahedron, 2015; 71: 9408-9414.

(R)-(+)-2-Methyl-2-propanesulfinamide Upstream-Materialien And Downstream Produkte

(R)-(+)-2-Methyl-2-propanesulfinamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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