Tioxolon

Bezeichnung:Tioxolon

CAS-Nr4991-65-5

Englisch Name:Tioxolone

CBNumberCB2696092

SummenformelC7H4O3S

Molgewicht168.17

MOL-Datei4991-65-5.mol

Synonyma

Tioxolon

Tioxolon physikalisch-chemischer Eigenschaften

Schmelzpunkt	158-160 °C(lit.)
Siedepunkt	267.1°C (rough estimate)
Dichte	1.4844 (rough estimate)
Brechungsindex	1.5151 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow
Aggregatzustand	A solid
pka	8.14±0.20(Predicted)
Farbe	Light yellow to yellow
Merck	9456
LogP	1.770 (est)
CAS Datenbank	4991-65-5(CAS DataBase Reference)
NIST chemische Informationen	Tioxolone(4991-65-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	DM2953750
HS Code	2934999090

Gefahreninformationscode (GHS)

Tioxolone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
light yellow to beige powder
Originator
Acnosan,Unia
Verwenden
6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.
Verwenden
antiseborrhoic
Definition
ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.
Manufacturing Process
40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.
Therapeutic Function
Antiseborreic, Antifungal, Keratolytic
Allgemeine Beschreibung
Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

Tioxolone Upstream-Materialien And Downstream Produkte

Tioxolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4991-65-5, Tioxolone Verwandte Suche:

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