2,2'-[Ethylenbis(oxy)]bisessigsure

Bezeichnung:2,2'-[Ethylenbis(oxy)]bisessigsure

CAS-Nr23243-68-7

Englisch Name:3,6-DIOXAOCTANEDIOIC ACID

CBNumberCB2499237

SummenformelC6H10O6

Molgewicht178.14

MOL-Datei23243-68-7.mol

Synonyma

2,2'-[Ethylenbis(oxy)]bisessigsure

2,2'-[Ethylenbis(oxy)]bisessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	68-71℃
Siedepunkt	429.2±25.0 °C(Predicted)
Dichte	1.375
Dampfdruck	0Pa at 20℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	3.09±0.10(Predicted)
Aggregatzustand	solid
Farbe	White to off-white
LogP	-2.29 at 25℃

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34
S-Sätze:	26-36/37/39-45-27-22
RIDADR	3261
HazardClass	8
PackingGroup	III
HS Code	2917198090

Gefahreninformationscode (GHS)

3,6-DIOXAOCTANEDIOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S22:Staub nicht einatmen.
Beschreibung
PEG2-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Verwenden
3,6-Dioxaoctanedioic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Verwenden
3,6-Dioxaoctanedioic Acid is a useful reagent for the preparation of degradation agents for cyclin dependent kinase.
Flammability and Explosibility
Not classified
Synthese

To 15 ml (0.33 mol) of nitric acid was added at 45??C while stirring 1 g of diethylene glycol from the overall amount of 5.9 g (0.06 mol), and the mixture was heated to 65??C. After the end of nitrogen oxides evolution and cooling the mixture to 45-50??C another portion of diethylene glycol was added. Overall time of the reagent addition to the reaction mixture was 1 h. The mixture was kept at 45??C for 40 min and then it was heated at 80??C for 30 min. The solvent was removed in a vacuum at 70??C, the residue was dried by azeotropic distillation with benzene using Dean-Stark trap, then the product was fi ltered off and recrystallized from acetone-benzene mixture. 3,6-Dioxaoctanedioic acid (VIII) was similarly obtained. Yield 7.3 g (89%), colorless crystals. Rf 0.20 (E), mp 76-77??C (mp 75-76??C [13]). IR spectrum, |í, cm-1: 3167 (OH), 2914 (CH), 1733 (C=O acid), 1410, 1229 (C-O), 1121 (C-O). Mass spectrum, m/z (Irel, %): 178.5 [M]+ (76), 200.9 (55), 216.8 (46).

3,6-DIOXAOCTANEDIOIC ACID Upstream-Materialien And Downstream Produkte

2,2'-[Ethylenbis(oxy)]bisessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

23243-68-7, 3,6-DIOXAOCTANEDIOIC ACID Verwandte Suche:

Send Inquriy