Suprofen

Bezeichnung:Suprofen

Englisch Name:Suprofen

CBNumberCB2496867

SummenformelC14H12O3S

Molgewicht260.31

Synonyma

Suprofen

Suprofen physikalisch-chemischer Eigenschaften

Schmelzpunkt	278°C
Siedepunkt	373.57°C (rough estimate)
Dichte	1.2959 (rough estimate)
Brechungsindex	1.5050 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.5 mg/ml
pka	3.91(at 25℃)
Aggregatzustand	Powder
Wasserlöslichkeit	soluble
CAS Datenbank	40828-46-4(CAS DataBase Reference)

Sicherheit

RIDADR	3249
HazardClass	6.1(b)
PackingGroup	III
HS Code	2934990002
Toxizität	LD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers)

Gefahreninformationscode (GHS)

Beschreibung
Suprofen is an arylpropionic acid analgesic/antiinflammatory agent with close structural resemblance to ketoprofen. It is more potent in many assays than indomethacin and ketoprofen and appears better tolerated.
Chemische Eigenschaften
Off-White to Light-Brown
Originator
Janssen (Belgium)
Verwenden
Prostaglandin biosynthesis inhibitor. Analgesic
Verwenden
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Definition
ChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
Trademarks
Profenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.
Veterinary Drugs and Treatments
Suprofen is a non-steroidal anti-inflammatory agent similar to flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids that inhibit the cyclo-oxygenase enzymes responsible for conversion of arachadonic acid from cell membranes into various prostaglandins. These prostaglandins mediate certain aspects of ocular inflammation including disruption of the blood-aqueous barrier, uveal vasodilation, increases in intraocular pressure, and leakage of white blood cells and protein from uveal vessels into the aqueous humor. Prostaglandins cause iris sphincter constriction (miosis) independent of cholinergic mechanisms. Suprofen can inhibit this intraocular miosis and may also be useful in the management of uveal inflammation (usually in addition to topical steroids).