Amino-Tri-(carboxyethoxymethyl)-methane Struktur

Amino-Tri-(carboxyethoxymethyl)-methane

Bezeichnung:Amino-Tri-(carboxyethoxymethyl)-methane

Englisch Name:Amino-Tri-(carboxyethoxymethyl)-methane

CBNumberCB24849531

SummenformelC13H23NO9

Molgewicht337.32

Amino-Tri-(carboxyethoxymethyl)-methane physikalisch-chemischer Eigenschaften

Amino-Tri-(carboxyethoxymethyl)-methane Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Amino-Tri-(carboxyethoxymethyl)-methane is a branched molecule that is reactive towards carboxylic acids in the presence of HATU. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biologische Aktivität
Amino-Tri-(carboxyethoxymethyl)-methan is a cleavable PEG-based ADC linker that can be used to synthesize antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Cleavable