Fas/FasL Antagonist, Kp7-6 - Calbiochem

Fas/FasL Antagonist, Kp7-6 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

• Allgemeine Beschreibung

  An exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (K_d = 11.2 & 13.2 μM, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.

• Biochem/physiol Actions

  Product does not compete with ATP.

Fas/FasL Antagonist, Kp7-6 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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