Dihydrotachysterol

Bezeichnung:Dihydrotachysterol

CAS-Nr67-96-9

Englisch Name:Dihydrotachysterol

CBNumberCB2469405

SummenformelC28H46O

Molgewicht398.66

MOL-Datei67-96-9.mol

Synonyma

Dihydrotachysterol

Dihydrotachysterol physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-120°C
alpha	D22 +97.5° (chloroform)
Siedepunkt	461.8°C (rough estimate)
Dichte	0.9678 (rough estimate)
Brechungsindex	1.5100 (estimate)
storage temp.	2-8°C
Löslichkeit	Practically insoluble in water, freely soluble in acetone and hexane, sparingly soluble in ethanol (96 per cent).
pka	14.96±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to off-white
Biologische Quelle	synthetic
Stabilität	Light sensitive
InChIKey	ILYCWAKSDCYMBB-KWOSLRGBSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	WW0600000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2936299055
Giftige Stoffe Daten	67-96-9(Hazardous Substances Data)
Toxizität	LD50 oral in mouse: 288mg/kg

Gefahreninformationscode (GHS)

Dihydrotachysterol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White Solid
Originator
Hytakerol,Winthrop,US,1950
Verwenden
Calcium regulator. Preparation by reduction of Tachysterol. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids.
Definition
ChEBI: A hydroxy seco-steroid that is 9,10-secoergosta-5,7,22-triene substituted by a hydroxy group at position 3. A synthetic analogue of vitamin D that acts a bone density conservation agent.
Manufacturing Process
The process of isolating chemically uniform crystalline dihydrotachysterol comprises subjecting the solution of the crude hydrogenation product of tachysterol in benzine to chromatographic adsorption by means of active aluminum oxide while collecting the components having a minor tendency of being adsorbed, subjecting the said components to a repeated chromatographic adsorption and converting the components having a minor tendency of being adsorbed into its ester by treatment with acetic anhydride in pyridine solution, isolating the ester formed from the reaction mixture, subjecting its solution in benzine to chromatographic adsorption while collecting the components having a minor tendency of being adsorbed, recrystallizing these components, saponifying the crystalline ester and recrystallizing the dihydrotachysterol obtained.
Trademarks
Hytakerol (Sterling Winthrop).
Therapeutic Function
Blood calcium regulator
Veterinary Drugs and Treatments
DHT is used in small animals to treat hypocalcemia secondary to hypoparathyroidism or severe renal disease.
läuterung methode
Crystallise the sterol from 90% MeOH, UV: max at 242, 251 and 261nm (E1% 760, 1010 and 650) in EtOH. The acetate has m108-110o and [] +32.8o (CHCl3), UV: max at 242, 251 and 261nm (E 780, 910 and 600) in EtOH. The propionate has m 97-98o and [] +37o (CHCl3), UV: max 242, 251 and 261nm (E 750, 860 and 570) in EtOH. [Werder Hoppe Seyler's Z Physiol Chem 260 119 1939, Windaus et al. Justus Liebigs Ann Chem 499 1978 1932, Beilstein 6 III 2833, 6 IV 3994, 4161.]

Dihydrotachysterol Upstream-Materialien And Downstream Produkte

Dihydrotachysterol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

67-96-9, Dihydrotachysterol Verwandte Suche:

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