MM-589 TFA salt

MM-589 TFA salt Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interactions. MM-MM-589 TFA binds WDR5 with an IC50 of 0.90 nM. IC50 for inhibition of MLL H3K4 methyltransferase activity is 12.7 nM.

• in vitro

  MM-589 TFA (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.

  Cell Viability Assay < table class="zh_use_1"> < tr>

  Cell Line:	MV4-11 and MOLM-13 cells
  Concentration:	0.01, 0.1, 1, 10 μM
  Incubation Time:	4 days or 7 days
  Result:	Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM.

• target

  IC50: 0.90 nM (WDR5), 12.7 nM (HMT)

  Ki: <1 nM (WDR5)

MM-589 TFA salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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