4'-CHLORO-3-METHOXYCINNAMANILIDE Struktur

4'-CHLORO-3-METHOXYCINNAMANILIDE

Bezeichnung:4'-CHLORO-3-METHOXYCINNAMANILIDE

CAS-Nr472981-92-3

Englisch Name:4'-CHLORO-3-METHOXYCINNAMANILIDE

CBNumberCB2449409

SummenformelC16H14ClNO2

Molgewicht287.74

MOL-Datei472981-92-3.mol

4'-CHLORO-3-METHOXYCINNAMANILIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-167℃
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: 13 mg/mL, soluble
Aggregatzustand	solid
Farbe	off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	2924.29.7790

4'-CHLORO-3-METHOXYCINNAMANILIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.
Verwenden
N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.
Verwenden
SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:
- to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
- to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
- to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)
Definition
ChEBI: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.
Biologische Aktivität
Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.
Lager
Store at RT
Einzelnachweise
1) Gunthorpe, et al., (2004) Identification and characterization of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist; Neuropharmacology 46 133 2) Varga et al. (2005) Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat; Neurosci. Lett.. 385 137

4'-CHLORO-3-METHOXYCINNAMANILIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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