SUCCINYL COENZYME A SODIUM SALT Struktur

SUCCINYL COENZYME A SODIUM SALT

Bezeichnung:SUCCINYL COENZYME A SODIUM SALT

CAS-Nr108347-97-3

Englisch Name:SUCCINYL COENZYME A SODIUM SALT

CBNumberCB2444570

SummenformelC25H41N7NaO19P3S

Molgewicht891.6

MOL-Datei108347-97-3.mol

SUCCINYL COENZYME A SODIUM SALT physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Löslichkeit	PBS (pH 7.2): 10 mg/ml
Aggregatzustand	A crystalline solid
Farbe	White to off-white

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	22-26-36
WGK Germany	3

Gefahreninformationscode (GHS)

SUCCINYL COENZYME A SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle. It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis. Succinyl-CoA deficiency, caused by vitamin B₁₂ deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.
Verwenden
Succinyl coenzyme A sodium salt has been used:
- for the nonenzymatic succinylation of lysine in vitro,
- as a substrate for adipic acid biosynthesis in recombinant E. coli
- in isocitrate dehydrogenase (ICDH)?treatment for the succinylation of proteins
- as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)
Biochem/physiol Actions
Succinyl CoA is an intermediate in the citric acid cycle. It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids. Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.
läuterung methode
If it should be purified further, then it should be dissolved in H2O (0.05g/mL) adjusted to pH 1 with 2M H2SO4 and extracted several times with Et2O. Excess Et2O is removed from the aqueous layer by bubbling N2 through it and is stored frozen at pH 1. When required, the pH should be adjusted to 7 with dilute NaOH and used within 2 weeks (samples should be frozen). Succinyl coenzyme A is estimated by the hydroxamic acid method [Hersch & Jencks J Biol Chem 242 3468 1967]. It is more stable in acidic than in neutral aqueous solutions, but neutral solutions can be stored at –15o with negligible decomposition. [Jordan & Laghai-Newton Methods Enzymol 123 435 1986, Beilstein 26 III/IV 3666.]

SUCCINYL COENZYME A SODIUM SALT Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

108347-97-3, SUCCINYL COENZYME A SODIUM SALT Verwandte Suche:

Send Inquriy