Erythromycinstearat

Bezeichnung:Erythromycinstearat

CAS-Nr643-22-1

Englisch Name:Erythromycin stearate

CBNumberCB2436793

SummenformelC55H103NO15

Molgewicht1018.42

MOL-Datei643-22-1.mol

Synonyma

Erythromycinstearat

Erythromycinstearat physikalisch-chemischer Eigenschaften

Schmelzpunkt	77-79°C
storage temp.	2-8°C
Löslichkeit	ethanol: soluble50mg/mL, clear to very slightly hazy, colorless
Farbe	white to off-white
Stabilität	Stable. Combustible. Incompatible with acids, strong oxidizing agents.
EPA chemische Informationen	Erythromycin stearate (643-22-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	42/43-36/37/38
S-Sätze:	36-26
WGK Germany	2
RTECS-Nr.	KF5785000
HS Code	29415000
Giftige Stoffe Daten	643-22-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Erythromycin stearate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White Solid
Originator
Erythrocin Stearate,Abbott,US,1952
Verwenden
Macrodiles antibacterial
Verwenden
Semi-synthetic macrolide antibiotic. Antibacterial
Verwenden
oil lubricant, plasticizer, solvent
Definition
ChEBI: Erythromycin stearate is an aminoglycoside.
Manufacturing Process
To a well-stirred solution of 3.18 grams (10.5 mmol) of stearoyl chloride and 1.24 grams (11.0 mmol) of 1-ethylpiperidine in 50 ml of methylene chloride is added 7.20 grams (10.0 mmol) of erythromycin. After a short time complete solution is obtained and stirring is then discontinued. The solution is allowed to stand overnight. The solution is diluted to 250 ml by the addition of methylene chloride and washed three times with 100 ml portions of water followed by two washes with 5% sodium bicarbonate solution. The organic layer is dried over anhydrous sodium sulfate and filtered, the solvent being removed under diminished pressure. The product is dried to constant weightat room temperature in a vacuum desiccator.
Trademarks
Bristamycin (Bristol-Myers Squibb); Erythrocin (Abbott).
Therapeutic Function
Antibacterial
Allgemeine Beschreibung
Erythromycin stearate (Ethril, Wyamycin S, Erypar) is thestearic acid salt of erythromycin. Like erythromycin base,the stearate is acid labile. It is film coated to protect it fromacid degradation in the stomach. In the alkaline pH of theduodenum, the free base is liberated from the stearateand absorbed. Erythromycin stearate is a crystalline powderthat is practically insoluble in water but soluble in alcoholand ether.
Allgemeine Beschreibung
Fluffy colorless powder or fine white powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
A base. Readily forms salts with acids.
Brandgefahr
Flash point data for Erythromycin stearate are not available; however, Erythromycin stearate is probably combustible.

Erythromycin stearate Upstream-Materialien And Downstream Produkte

Erythromycinstearat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

643-22-1, Erythromycin stearate Verwandte Suche:

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