C8 CERAMIDE Struktur

C8 CERAMIDE

Bezeichnung:C8 CERAMIDE

CAS-Nr74713-59-0

Englisch Name:C8 CERAMIDE

CBNumberCB2432038

SummenformelC26H51NO3

Molgewicht425.69

MOL-Datei74713-59-0.mol

C8 CERAMIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	68-70°C
Siedepunkt	541.37°C (rough estimate)
Dichte	0.9974 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	−20°C
Löslichkeit	DMSO or ethanol: soluble
Aggregatzustand	waxy solid
Farbe	White
Stabilität	Temperature Sensitive
CAS Datenbank	74713-59-0(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29225000

Gefahreninformationscode (GHS)

C8 CERAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1?Induces apoptosis.2?Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver epithelial cells.3?C8-ceramide induces the secretion of brain-derived neurotrophic factor (BDNF) from microglia?in vitro.4
Chemische Eigenschaften
Off White Powder
Verwenden
A biologically active, cell permeable, but nonphysiologic ceramide analog. It induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. It stimulates IL-2 secretion and induces apoptosis
Verwenden
C-8 Ceramide is a ceramide analog.
Definition
ChEBI: N-octanoylsphingosine is an N-acylsphingosine in which the ceramide N-acyl group is specified as octanoyl. It is functionally related to an octanoic acid.
Einzelnachweise
1) Mathias?et al. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha; Proc. Natl. Acad. Sci. USA,?88?109 2) Jarvis?et al. (1993)?Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway; Proc. Natl. Acad. Sci. USA?91?73 3) Upham?et al. (2003),?Differential roles of 2,6 and 8 carbon ceramides on the modulation of gap junctional communication and apoptosis during carcinogenesis; Cancer Lett.,?191?27 4) Nakajima?et al. (2002),?Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro; J. Neurochem.,?80?697

C8 CERAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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