(-)-D-Argininhydrat

Bezeichnung:(-)-D-Argininhydrat

CAS-Nr157-06-2

Englisch Name:D(-)-Arginine

CBNumberCB2408147

SummenformelC6H14N4O2

Molgewicht174.2

MOL-Datei157-06-2.mol

Synonyma

(-)-D-Argininhydrat

(-)-D-Argininhydrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	226 °C (dec.) (lit.)
alpha	-28.5 º (c=8, 6 N HCl)
Siedepunkt	305.18°C (rough estimate)
Dichte	1.2297 (rough estimate)
Brechungsindex	-23 ° (C=8, 6mol/L HCl)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	Aqueous Acid (Slightly), Water (Slightly)
Aggregatzustand	Solid
pka	2.49±0.24(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	SOLUBLE
Sensitive	Air Sensitive
BRN	1725412
InChIKey	ODKSFYDXXFIFQN-SCSAIBSYSA-N
LogP	-0.999 (est)
CAS Datenbank	157-06-2(CAS DataBase Reference)
EPA chemische Informationen	D-Arginine (157-06-2)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36-36/37/38-20/21/22
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	CF1934220
F	9
TSCA	Yes
HazardClass	IRRITANT
HS Code	29252000

Gefahreninformationscode (GHS)

D(-)-Arginine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
D-arginine is the D-form of arginine, which is a kind of amino acids. It can be reacted with hydrogen peroxide for non-enzymatic synthesis of nitric oxide. It has certain pharmacological activities. For example, its derivative, 1-deamino-8-D-arginine vasopressin is useful for the management of haemophilia and von Willebrand’s disease. It also has the potential to inhibit the proliferation of certain cancer cells. In biological research, D-arginine is frequently used in the studies of L-arginine/nitric oxide pathway as an inactive form of L-arginine.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
1-Deamino-8-D-arginine vasopressin makes a new pharmacological approach to the management of haemophilia and von Willebrand's disease. A novel nonenzymatic pathway for the generation of nitric oxide is by the reaction of hydrogen peroxide and d- or l-arginine.
Verwenden
Arginine is an essential amino acid found in food and plant sources, and many biological systems.
D-Arginine is extensively used in studies on L-arginine/nitric oxide pathway as an inactive form of L-arginine, even in man.
D-Arginine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). D-Arginine can be found in human epidermis and platelet tissues. Within the cell, D-arginine is primarily located in the peroxisome. D-Arginine specifically can inhibit arginine decarboxylase enzymes and also functions as a metabolite.
Definition
ChEBI: A D-alpha-amino acid that is the D-isomer of arginine.
Einzelnachweise
https://www.alfa.com/zh-cn/catalog/A16137/
Iannucci, N. B., et al. "Antiproliferative effect of 1-deamino-8-D-arginine vasopressin analogs on human breast cancer cells." Future Medicinal Chemistry 3.16(2011):1987-1993.
Ripoll, Giselle, et al. "Angiostatic activity of 1-Deamino-8-D-Arginine vasopressin and novel peptide analogues in breast cancer cells." Cancer Research 68(2008).
Navarro, Eduardo, et al. "Toxicological and Pharmacological Effects of D-Arginine." Basic & Clinical Pharmacology & Toxicology97.3(2005):149-154.

D(-)-Arginine Upstream-Materialien And Downstream Produkte

(-)-D-Argininhydrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

157-06-2, D(-)-Arginine Verwandte Suche:

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