Methoxychlor

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

METHOXYCHLOR Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE BIS HELLGELBE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen und Verbrennen unter Bildung giftiger und ätzender Gase mit Chlorwasserstoff, s. ICSC 0163. Reagiert mit Oxidationsmitteln. Greift einige Kunststoffe und Gummi an.

• ARBEITSPLATZGRENZWERTE

  TLV: 10 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
  MAK: 15 mg/m? (Einatembare Fraktion) Spitzenbegrenzung: überschreitungsfaktor II(8); Schwangerschaft: Gruppe D; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Versprühen oder Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Beim Verschlucken großer Mengen sind Auswirkungen auf Leber, Nieren und Zentralnervensystem möglich. Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel.

• R-Sätze Betriebsanweisung:

  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  R40:Verdacht auf krebserzeugende Wirkung.
  R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
  R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  R11:Leichtentzündlich.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R38:Reizt die Haut.

• S-Sätze Betriebsanweisung:

  S7:Behälter dicht geschlossen halten.
  S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.

• Beschreibung

  Methoxychlor is a structural analogue of DDT but is not as persistent in the environment as DDT.

• Chemische Eigenschaften

  Methoxychlor is a colourless or pale yellow, crystalline synthetic organochlorine insecticide with mild fruity odour. It is available in the form of powder or crystals. Methoxychlor is moderately soluble in water and is soluble in a variety of organic solvents.

• Physikalische Eigenschaften

  White to gray, or pale yellowish-orange crystals or powder. Nonflammable but may be combustible if dissolved in a flammable organic solvent or petroleum distillate for application. Pungent to mild, fruity odor. Odor threshold concentration in water is 4.7 mg/kg (quoted, Keith and Walters, 1992).

• Verwenden

  Methoxychlor is effective against flies, mosquitos, cockroaches, and a wide variety of other insects. This insecticide is used on agricultural crops and livestock, and in animal feed, barns, and grain storage bins. Some pesticide products that contain methoxychlor are used for controlling insects in gardens or on pets.

• Verwenden

  Insecticide used to control mosquito larvae, house flies and other insect pests in field crops, fruits and vegetables; to control ecto-parasites on cattle, sheep and goats; recommended for use in dairy barns.

• Verwenden

  Insecticide effective against mosquito larvae and house flies; recommended for use in dairy barns.

• Definition

  ChEBI: Methoxychlor is an organochlorine insecticide. It is functionally related to a 1,1,1-trichloro-2,2-diphenylethane.

• Allgemeine Beschreibung

  METHOXYCHLOR is a white crystalline solid which is often dissolved in a liquid carrier such as diesel oil. METHOXYCHLOR can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. If dissolved in a liquid carrier, METHOXYCHLOR can easily penetrate the soil and contaminate groundwater and nearby streams. METHOXYCHLOR is used as a pesticide.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  METHOXYCHLOR turns pink or tan on exposure to light. METHOXYCHLOR is incompatible with alkaline materials, especially in the presence of catalytically-active metals. METHOXYCHLOR is slightly corrosive to iron and aluminum. METHOXYCHLOR is decomposed by refluxing with sodium in isopropyl alcohol. METHOXYCHLOR is also incompatible with strong oxidizers. METHOXYCHLOR will attack some forms of plastics, rubber and coatings. .

• Hazard

  Toxic material. Liver damage and central nervous system impairment. Questionable carcinogen.

• Health Hazard

  Low toxicity; acute and chronic effects aremuch less serious than those of the structurally similar DDT; skin absorption low;may cause kidney damage on chronic exposure; oral LD50 value (rats): 6000 mg/kg(ACGIH 1986); no evidence of carcinogenicity to animals or humans; exposure limit:TLV-TWA 10 mg/m³ (ACGIH, MSHA, andOSHA); RCRA Waste Number U247
  Methoxychlor is a reproductive toxicant.Exposure of young adult male rats to methoxychlor reduced their serum testosterone levels (Murono et al. 2006). It metabolized in theliver into 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane and both methoxychlor and itsmetabolite were found to exhibit weak estrogenic and antiandrogenic activities. Flynnet al. (2005) have reported that long-termexposure to methoxychlor in diet altered thesexually dimorphic behavior in young ratsof both sexes. The study indicated that consumption of sodium solution increased in ratsfrom such exposure. The toxicity of methoxychlor, particularly in the central nervous system, may be attributed to its inhibition of brainmitochondrial respiration which probably iscaused by an increased production of reactiveoxygen species (Schuh et al. 2005).

• Health Hazard

  Toxicity is relatively low. Inhalation or ingestion causes generalized depression.

• Brandgefahr

  Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride gas may be formed in fire.

• Landwirtschaftliche Anwendung

  Insecticide: Not approved for use in EU countries . Not registered for use in the U.S. There are 33 global suppliers . The U.S. EPA lists 826 active and/or canceled products containing methoxychlor. Methoxychlor was introduced as an insecticide in 1945. It is a close relative of DDT and has been increasing in use since the ban on DDT in 1972 because of its very low mammalian toxicity for home and garden, on domestic animals for fly control, for elm bark-beetle vectors of Dutch elm disease, and for blackfly larvae in streams. Methoxychlor is registered for about 87 crops such as alfalfa; nearly all fruits and vegetables, corn, wheat, rice, and other grains; beef and dairy cattle; and swine, goats and sheep, and for agricultural premises and outdoor fogging. It is available in wettable and dust powders, emulsifiable concentrates, granules, and as an aerosol. It is combined in formulations with malathion, parathion, piperonyl butoxide, and pyrethrins.

• Handelsname

  CHEMFORM®; HIGALMETOX®; MARLATE®; METOX®; MOXIE®; PRENTOX®

• Sicherheitsprofil

  Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl-. See also DDT and CHLOROPHENOLS.

• mögliche Exposition

  Agricultural Chemical; Tumorigen, Mutagen; Reproductive Effector; Human Data. Methoxychlor was introduced as an 1734 Methoxychlor insecticide in 1945. It is a close relative of DDT and has been used as an insecticide of very low mammalian toxicity for home and garden, on domestic animals for fly control, for elm bark-beetle vectors of Dutch elm disease, and for blackfly larvae in streams. Methoxychlor is registered for about 87crops, alfalfa, nearly all fruits and vegetables, corn, wheat, rice, and other grains, beef and dairy cattle, and swine, goats and sheep, and for agricultural premises and outdoor fogging. Thus, those engaged in manufacture, formulation, and application of the material as well as people in application areas may be exposed.

• Erste Hilfe

  If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

• Carcinogenicity

  Female mice fed up to 2000mg/kg and males given 3500 mg/kg in the diet for 78 weeks showed no statistically significant increase in the incidence of benign and malignant tumors that could be attributed to methoxychlor.10 Chronic feeding studies in rats, at 850 and 1400mg/kg for males and females, respectively, also showed no significant carcinogenic responses, although high tumor rates in controls may have masked detection.10 Based on NCI results and several earlier animal studies, the IARC has determined that there is insufficient evidence that methoxychlor is carcinogenic in experimental animals and that it is not classifiable as to its carcinogenicity to humans.

• Environmental Fate

  Biological. Degradation by the microorganism Aerobacter aerogenes under aerobic or anaerobic conditions yielded 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene and 1,1- dichloro-2,2-bis(p-methoxyphenyl)ethane (Mendel and Walton, 1966; Kobayashi and Rittman, 1982). Methoxychlor degrades at a faster rate in flooded/anaerobic soils than in nonflooded and aerobic soils (Fogel et al., 1982; Golovleva et al., 1984). In anaerobic soil, 90% of the applied dosage was lost after 3 months. In aerobic soil, only 0.3% was lost as carbon dioxide after 410 days (Fogel et al., 1982). In a modified river die-away test, methoxychlor underwent aerobic biodegradation at a rate of 0.0024/hour which corresponds to a half-life of 12 days (Cripe et al., 1987).
  In a model aquatic ecosystem, methoxychlor degraded to ethanol, dihydroxyethane, dihydroxyethylene and unidentified polar metabolites (Metcalf et al., 1971). Kapoor et al. (1970) also studied the biodegradation of methoxychlor in a model ecosystem contain
  From the first-order biotic and abiotic rate constants of methoxychlor in estuarine water and sediment/water systems, the estimated biodegradation half-lives were 208–8,837 and 12–45 days, respectively (Walker et al., 1988).
  Paris and Lewis (1976) reported that the microorganism Aspergillis sp. accumulated methoxychlor slowly, requiring 16 hours to reach equilibrium. Some microorganisms, such as Flavobacterium harrisonii, Bacillus subtilis and Chlorella pyrenoidoda accumulated methoxychlor and reached equilibrium in only 30 minutes.
  Groundwater. According to the U.S. EPA (1986) methoxychor has a high potential to leach to groundwater.

• Stoffwechselwegen

  Upon UV irradiation with methyl oleate, methoxychlor is extensively added to the carbon ? carbon double bond of methyl oleate via radical mechanisms. Besides chlorinated stearic acids, several addition products are formed, offering new possibilities to produce bound residues in plants. The incubation of methoxychlor with liver microsomes from untreated and phenobarbital-treated rats and donors, in the presence of NADPH, yields three phenolic metabolites: monodemethylated and didemethylated methoxychlor and its hydroxylated (trihydroxy) methoxychlor. The metabolic route of methoxychlor by monooxygenases involves sequential demethylations to the dihydroxy derivative and a subsequent ring hydroxylation.

• Solubility in water

  Soluble in ethanol (Windholz et al., 1983), chloroform (440 g/kg), xylene (440 g/kg), and methanol (50 g/kg) (Worthing and Hance, 1991)

• Lager

  Color Code—Blue: Health Hazard/Poison: Store in a secure poison location. Protect containers from damage. Store in cool, dry area away from fire hazard and out of direct sunlight.

• Versand/Shipping

  This material may be classed under Organochlorine Pesticides, solid, toxic, n.o.s. This compound requires a shipping label of “POISONOUS/TOXIC MATERIALS.” It falls in Hazard Class 6.1 and Packing Group III.

• läuterung methode

  Free the insecticide from 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane by crystallising from EtOH. It is dimorphic and also crystallises from Et2O/EtOH (m 92o). [Fritsch & Feldmann Justus Liebigs Ann Chem 306 77 1899, Smith et al. Aust J Chem 29 743 1976, Beilstein 6 H 1007.]

• Toxicity evaluation

  Acute oral LD₅₀ for rats: 6,000 mg/kg

• Degradation

  Methoxychlor is stable to oxidising agents and to ultraviolet light but it becomes pink or tan-coloured on irradiation. It reacts with alkalis, especially in the presence of catalytic metals, with the loss of hydrogen chloride to give 1,l-dichloro-2,2-bis(4-methoxyphenyl)ethylene(2).
  The major product of photolysis of methoxychlor in air-saturated water, irradiated at wavelengths >280 nm, was 2 while 1,1-dichloro-2,2-bis(4- methoxyphenyl)ethane (3) was formed along with 2 in degassed wateracetonitrile solutions. Subsequently, 2 was photolysed to benzaldehyde (Zepp et al., 1976). Products of photolysis in aqueous alcoholic solutions were 4,4’-dimethoxybenzophenone (4), 4-methoxybenzoic acid, and 4- methoxyphenol(5) (Wolfe et al., 1976). When methoxychlor was irradiated in milk by ultraviolet light (carbon arc, 220-330 nm) compounds 4 and 5, 4-methylanisole (6), 1,1,4,4-tetrakis(4-methoxyphenyl)-2,3-dichloro-2- butene (7) and 1,1,4,4-tetrakis(4-methoxyphenyl)-1,2,3-butatriene(8) were identified as products (Li and Bradley, 1969) (Scheme 1).
  In water, chemical decomposition was slow and at 27 °C the DT₅₀ at pH 5 to 9 was 100 days. Major products of hydrolysis are anisoin (9), anisil (10) and 2 (Wolfe et al., 1977) (see Scheme 2).

• Inkompatibilitäten

  Oxidizers.

METHOXYCHLOR Upstream-Materialien And Downstream Produkte

Methoxychlor Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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