2-Phenylacetamid

Bezeichnung:2-Phenylacetamid

CAS-Nr103-81-1

Englisch Name:2-Phenylacetamide

CBNumberCB2360953

SummenformelC8H9NO

Molgewicht135.16

MOL-Datei103-81-1.mol

Synonyma

2-Phenylacetamid

2-Phenylacetamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	156 °C
Siedepunkt	280-290 °C (dec.)
Dichte	1.1031 (rough estimate)
Brechungsindex	1.5589 (estimate)
storage temp.	Refrigerator
Löslichkeit	Soluble in methanol.
pka	16.21±0.40(Predicted)
Aggregatzustand	Solid
Farbe	Plates or leaflets
Merck	14,7266
InChI	InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
InChIKey	LSBDFXRDZJMBSC-UHFFFAOYSA-N
SMILES	C1(CC(N)=O)=CC=CC=C1
CAS Datenbank	103-81-1(CAS DataBase Reference)
NIST chemische Informationen	Benzeneacetamide(103-81-1)
EPA chemische Informationen	Benzeneacetamide (103-81-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	22-36
S-Sätze:	22-24/25-60-36-26
RTECS-Nr.	AC7705000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29242990
Toxizität	LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76

Gefahreninformationscode (GHS)

2-Phenylacetamide Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
2-Phenylacetamide, also known as alpha-toluamide or benzeneacetamide, belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. Pure crystals are plate shaped and colorless to white. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene.
Verwenden
In agriculture, 2-Phenylacetamid can be used in the production of many important intermediates of pesticides, such as carbamine. In the field of dyes: it can react with some monomers with color to produce some important raw materials for blue and purple dyes. In the field of fragrances, it can be used as an important raw material for the synthesis of certain spices and flavors. 2-Phenylacetamide can also be used in the synthesis of organometallic, organic peroxide, organic peroxide ester, and other compounds, and can be used as a crosslinking agent for polymers, a film forming agent for coatings, a plasticizer for plastics, etc.
Verwenden
2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.
synthetische
Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide.
Definition
ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid.
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
Organic Syntheses, Coll. Vol. 4, p. 760, 1963
Biologische Aktivität
2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
läuterung methode
Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]

2-Phenylacetamide Upstream-Materialien And Downstream Produkte

2-Phenylacetamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

103-81-1, 2-Phenylacetamide Verwandte Suche:

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