5-Bromoisatoic anhydride

Bezeichnung:5-Bromoisatoic anhydride

CAS-Nr4692-98-2

Englisch Name:5-Bromoisatoic anhydride

CBNumberCB2341787

SummenformelC8H4BrNO3

Molgewicht242.03

MOL-Datei4692-98-2.mol

5-Bromoisatoic anhydride physikalisch-chemischer Eigenschaften

Schmelzpunkt	280-285 °C (dec.) (lit.)
Dichte	1.826±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	soluble in Dimethylformamide
Aggregatzustand	powder to crystal
pka	9.81±0.20(Predicted)
Farbe	White to Light yellow to Light orange
CAS Datenbank	4692-98-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	61-20/21-36/37/38
S-Sätze:	53-23-36/37/39-45
WGK Germany	3
Hazard Note	Irritant
HazardClass	IRRITANT, IRRITANT-HARMFUL
HS Code	29349990

Gefahreninformationscode (GHS)

5-Bromoisatoic anhydride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R61:Kann das Kind im Mutterleib schädigen.
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Off-white to salmon powder
Verwenden
5-Bromoisatoic anhydride is an important chemical raw material and pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.
synthetische
5-Bromoisatoic anhydride is prepared from 5-bromo indole by stirring in a 4:1 mixture of DMF/H2O for 16 h at room temperature.
1HNMR(DMSO-d6): δ 11.85 (s, br., 1H), 7.96 (dd, J = 0.8, 8.7 Hz, 1H), 7.87 (dd, J = 2.3, 8.7 Hz, 1H), 7.09 (dd, J = 8.8, 0.8 Hz, 1H).
Synthese

87-48-9

4692-98-2

General procedure for the synthesis of 6-bromo-2H-benzo[d][1,3]oxazine-2,4(1H)-dione using 5-bromoindigo red as starting material: 5-bromoindigo red (II) (20.0 g, 88.49 mmol) was uniformly dispersed in dichloromethane (300 mL), and m-chloroperoxybenzoic acid (22.91 g, 132.73 mmol) was added in batches at room temperature. at room temperature. The reaction mixture was stirred at room temperature for 2 h. The reaction progress was monitored by thin layer chromatography (TLC) to confirm the completion of the reaction. Subsequently, the reaction system was cooled to 10°C with continuous stirring and sodium bisulfite solution was slowly added dropwise until the starch potassium iodide paper no longer showed color. The reaction solution was concentrated by rotary evaporation to remove dichloromethane, 50 mL of water was added to mix well with the residue, and then saturated sodium bicarbonate solution was added dropwise until no bubbles were produced. The resulting solid was collected by filtration, washed with a small amount of water and dried at 50 °C to give 20.99 g of 5-bromoisatoindirubic anhydride (III) in 98% yield.
Einzelnachweise
[1] Patent: CN106632276, 2017, A. Location in patent: Paragraph 0112; 0113; 0114
[2] Angewandte Chemie, 1980, vol. 92, # 3, p. 196 - 197
[3] Catalysis Science and Technology, 2015, vol. 5, # 10, p. 4830 - 4838
[4] Patent: CN103570726, 2016, B. Location in patent: Paragraph 0085; 0086; 0087
[5] Journal fuer Praktische Chemie (Leipzig), 1886, vol. <2> 33, p. 36

5-Bromoisatoic anhydride Upstream-Materialien And Downstream Produkte

5-Bromoisatoic anhydride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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