N-Hydroxyphthalimid

Bezeichnung:N-Hydroxyphthalimid

CAS-Nr524-38-9

Englisch Name:N-Hydroxyphthalimide

CBNumberCB2332640

SummenformelC8H5NO3

Molgewicht163.13

MOL-Datei524-38-9.mol

Synonyma

N-Hydroxyphthalimid

N-Hydroxyphthalimid physikalisch-chemischer Eigenschaften

Schmelzpunkt	233 °C (dec.) (lit.)
Siedepunkt	290.19°C (rough estimate)
Dichte	1.64 g/cm3
Dampfdruck	0Pa at 25℃
Brechungsindex	1.5510 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	6.10±0.20(Predicted)
Aggregatzustand	Powder
Farbe	Yellow
Wasserlöslichkeit	Slightly soluble in water.
Merck	14,4838
BRN	131208
InChIKey	CFMZSMGAMPBRBE-UHFFFAOYSA-N
LogP	0.14
CAS Datenbank	524-38-9(CAS DataBase Reference)
EPA chemische Informationen	1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	TI5200000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29251995

Gefahreninformationscode (GHS)

N-Hydroxyphthalimide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
N-Hydroxyphthalimide is yellow moist powder
Verwenden
Catalyst for oxidation reactions.
Verwenden
Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts.
Verwenden
N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.
Application
N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0
läuterung methode
N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]

N-Hydroxyphthalimide Upstream-Materialien And Downstream Produkte

N-Hydroxyphthalimid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

524-38-9, N-Hydroxyphthalimide Verwandte Suche:

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