Troxerutin

Bezeichnung:Troxerutin

CAS-Nr7085-55-4

Englisch Name:Troxerutin

CBNumberCB2317568

SummenformelC33H42O19

Molgewicht742.68

MOL-Datei7085-55-4.mol

Synonyma

Troxerutin

Troxerutin physikalisch-chemischer Eigenschaften

Schmelzpunkt	181°C
Siedepunkt	1058.4±65.0 °C(Predicted)
Dichte	1.65±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
pka	5.92±0.40(Predicted)
Farbe	Light Yellow to Yellow
Merck	14,9789
BRN	4778232
InChIKey	KMPBUGGPUQOWMJ-NXPSPVSKSA-N
CAS Datenbank	7085-55-4(CAS DataBase Reference)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	LK8331500
HS Code	2938100000

Gefahreninformationscode (GHS)

Troxerutin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Yellow Powder
Originator
Venoruton,Novartis Co
Verwenden
vasoprotectant
Verwenden
Used in the treatment of venous disorders
Verwenden
Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.
Manufacturing Process
In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland
Therapeutic Function
Topical venotonic
target
VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt

Troxerutin Upstream-Materialien And Downstream Produkte

Troxerutin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7085-55-4, Troxerutin Verwandte Suche:

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