WAY-151932

WAY-151932 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively.

• in vitro

  WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV ₂ receptors in a dose-dependent manner with an EC ₅₀ of 0.74±0.07 nM.

• in vivo

  Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED ₅₀ =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile.

• target

  IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding)

WAY-151932 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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