Sp-8-bromo-Cyclic AMPS (sodium salt)

Sp-8-bromo-Cyclic AMPS (sodium salt) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.^1,2 This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP and Sp-cAMPS . Sp-8-bromo-cAMPS is a PKA agonist (EC₅₀ = 1.5 μM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.^3,4

• Verwenden

  8-Bromoadenosine 3',5'-Cyclic Monophosphothioate Sp-Isomer Sodium Salt is an activator of cAMP-dependent PKA.

• Einzelnachweise

  1. Yokozaki, H., Tortora, G., Pepe, S., et al. Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells Cancer Res. 52(9),2504-2508(1992).
  2. Dostmann, W.R., Taylor, S.S., Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates J. Biol. Chem. 265(18),10484-10491(1990).
  3. Schwede, F., Maronde, F., Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs Pharmacol. Ther. 87(2),199-226(2000).
  4. Schaap, P., van Ments-Cohen, M., Soede, R.D., et al. Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium J. Biol. Chem. 268(9),6323-6331(1993).

Sp-8-bromo-Cyclic AMPS (sodium salt) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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