Mal-PEG1-NHS ester Struktur

Mal-PEG1-NHS ester

Bezeichnung:Mal-PEG1-NHS ester

Englisch Name:Mal-PEG1-NHS ester

CBNumberCB23062526

SummenformelC13H14N2O7

Molgewicht310.26

Mal-PEG1-NHS ester physikalisch-chemischer Eigenschaften

Mal-PEG1-NHS ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Biologische Aktivität
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs