5,5-Diphenyl-2,4-imidazolidindion,Natriumsalz

Bezeichnung:5,5-Diphenyl-2,4-imidazolidindion,Natriumsalz

CAS-Nr630-93-3

Englisch Name:Phenytoin sodium

CBNumberCB2304645

SummenformelC15H13N2NaO2

Molgewicht276.27

MOL-Datei630-93-3.mol

Synonyma

Phenytoinnatrium

5,5-Diphenyl-2,4-imidazolidindion,Natriumsalz

5,5-Diphenyl-2,4-imidazolidindion,Natriumsalz physikalisch-chemischer Eigenschaften

storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	aqueous base: soluble
Aggregatzustand	Crystalline Powder
Farbe	White to almost white
Merck	14,7322
BCS Class	2
Stabilität	Hygroscopic
InChIKey	FJPYVLNWWICYDW-UHFFFAOYSA-M
CAS Datenbank	630-93-3(CAS DataBase Reference)
EPA chemische Informationen	Diphenylhydantoin sodium (630-93-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-43-62-63
S-Sätze:	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	MU1400000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29332100
Toxizität	LD50 orally in mice: 490 mg/kg (Fink, Swinyard)

Gefahreninformationscode (GHS)

Phenytoin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White or almost white, crystalline powder, slightly hygroscopic.
Verwenden
antibacterial
Verwenden
5,5-Diphenylhydantoin sodium salt has been used:
- in the cream preparation for treating burn wounds
- in seizure behavior testing as an anticonvulsant in Drosophila
- in in vivo embryo toxicity test in mouse embryonic stem cells
Verwenden
Antiepileptic
Trademarks
Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].
Allgemeine Beschreibung
Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
Clinical Use
Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
Sicherheitsprofil
Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
Carcinogenicity
Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
Solubility in water
1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.

Phenytoin sodium Upstream-Materialien And Downstream Produkte

5,5-Diphenyl-2,4-imidazolidindion,Natriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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