Tris(dibenzylideneacetone)dipalladium-chloroform adduct

Bezeichnung:Tris(dibenzylideneacetone)dipalladium-chloroform adduct

CAS-Nr52522-40-4

Englisch Name:Tris(dibenzylideneacetone)dipalladium-chloroform adduct

CBNumberCB2298434

SummenformelC52H31Cl3O3Pd2

Molgewicht1023.01

MOL-Datei52522-40-4.mol

Tris(dibenzylideneacetone)dipalladium-chloroform adduct physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-135 °C(lit.)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Aggregatzustand	Crystalline Powder
Farbe	Purple to black
Wasserlöslichkeit	Soluble in organic solvents. Insoluble in water.
Sensitive	Air & Moisture Sensitive
InChI	InChI=1S/3C17H10O.CHCl3.2Pd/c318-17(13-11-15-7-3-1-4-8-15)14-12-16-9-5-2-6-10-16;2-1(3)4;;/h31-10H;1H;;
InChIKey	NLYJPAJWGANOKG-CXKPDERJSA-N
SMILES	C(Cl)(Cl)Cl.O=C1C2=C(C3C=CC=CC=3)[Pd]3452C(C2C=CC=CC=2)=C3C(=O)C2=C(C3C=CC=CC=3)[Pd]362(C(C2C=CC=CC=2)=C3C(=O)C4=C5C2C=CC=CC=2)C(C2C=CC=CC=2)=C16

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-38-40-48/20/22-36/37/38
S-Sätze:	36/37-37/39-26
WGK Germany	3
TSCA	No
HS Code	28439000

Gefahreninformationscode (GHS)

Tris(dibenzylideneacetone)dipalladium-chloroform adduct Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
purple to black crystalline powder
Verwenden
Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct is a catalyst that is used in the preparation of anticancer activity of amino vinylindoles via palladium catalyzed coupling of hydrazone, haloindoles and amines.
Verwenden
suzuki reaction
Application
Tris(dibenzylideneacetone)dipalladium-chloroform adduct (Pd2dba3·CHCl3) was used in the following studies:
To compose the catalytic system for the preparation of homoallylpalladium complexes.These complexes underwent in situ Stille type cross coupling with various vinyltin reagents to afford the cyclized products bearing allyl appendages.
As palladium source in the asymmetric transformations of 3,4-epoxy-1-butene.
As catalyst for the Heck cross-coupling reaction of iodobenzene with styrene.
As cyclization catalyst.
As catalyst for [2+2+2] cycloaddtion of didehydrotriphenylenes to the corresponding extended triphenylenes.
As catalyst for the carbonylation of b,b-imidoyl iodides to the corresponding imidate esters used, in turn, to prepare cyclic, quaternary amino acids.
Allgemeine Beschreibung
Tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct (Pd₂dba₃·CHCl₃) is reported to serve as effective precatalysts, or precursors to the active Pd(0) catalyst.
reaction suitability
core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
Biologische Aktivität
N -myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo . Also used as a cyclization catalyst.

Tris(dibenzylideneacetone)dipalladium-chloroform adduct Upstream-Materialien And Downstream Produkte

Tris(dibenzylideneacetone)dipalladium-chloroform adduct Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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