TYRPHOSTIN B7 Struktur

TYRPHOSTIN B7

Bezeichnung:TYRPHOSTIN B7

CAS-Nr134036-53-6

Englisch Name:TYRPHOSTIN B7

CBNumberCB2288901

SummenformelC15H9N5

Molgewicht259.27

MOL-Datei134036-53-6.mol

TYRPHOSTIN B7 physikalisch-chemischer Eigenschaften

Siedepunkt	714.1±60.0 °C(Predicted)
Dichte	1.396±0.06 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	DMSO: soluble
pka	15.95±0.30(Predicted)
Aggregatzustand	Yellow solid.

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3

TYRPHOSTIN B7 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC₅₀ value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC₅₀ = 820 μM).
Definition
ChEBI: AG-370 is a member of indoles.
in vitro
previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1].
IC 50
20 μm for pdgf receptor kinase in human bone marrow fibroblasts
Einzelnachweise
[1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992).

TYRPHOSTIN B7 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

134036-53-6, TYRPHOSTIN B7 Verwandte Suche:

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