3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine Struktur

3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

Bezeichnung:3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

Englisch Name:3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine

CBNumberCB22717362

SummenformelC23H49NO11

Molgewicht515.64

3,6,9,12,15,18,21,24,27,30,33-Undecaoxatetratriacontan-1-amine physikalisch-chemischer Eigenschaften

Gefahreninformationscode (GHS)

Beschreibung
m-PEG11-amine is a water soluble PEG linker containing an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media.
Biologische Aktivität
M-PEG11-Amino is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

target

Cleavable

PEGs