Diallyltrisulfid

Bezeichnung:Diallyltrisulfid

CAS-Nr2050-87-5

Englisch Name:Diallyl trisulfide

CBNumberCB2269270

SummenformelC6H10S3

Molgewicht178.34

MOL-Datei2050-87-5.mol

Synonyma

Diallyltrisulfid

Diallyltrisulfid physikalisch-chemischer Eigenschaften

Siedepunkt	bp6 92°; bp0.0008 66-67°
Dichte	1.085
FEMA	3265 \| DIALLYL TRISULFIDE
Brechungsindex	nD20 1.5896
storage temp.	-20°C
Löslichkeit	Soluble in acetone, Ethanol(~3 mg/ml), DMSO (~5 mg/ml), and DMF (~10 mg/ml).
Aggregatzustand	oil
Farbe	Colorless to light yellow
Geruch (Odor)	at 0.10 % in propylene glycol. garlic green onion metallic
Geruchsart	sulfurous
Wasserlöslichkeit	insoluble in water.
JECFA Number	587
InChI	InChI=1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChIKey	UBAXRAHSPKWNCX-UHFFFAOYSA-N
SMILES	S(SCC=C)SCC=C
LogP	4.59
CAS Datenbank	2050-87-5(CAS DataBase Reference)
NIST chemische Informationen	Trisulfide, di-2-propenyl(2050-87-5)

Sicherheit

RIDADR	2810
WGK Germany	3
RTECS-Nr.	BC6168000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29309090

Gefahreninformationscode (GHS)

Diallyl trisulfide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Hydrogen sulfide (H2S) is an endogenously-produced gaseous second messenger that can regulate many physiological processes. Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic that acts as an H2S donor. It reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM). DATS suppresses the growth of PC-3 xenografts in vivo in mice and induces vascular smooth muscle relaxation. Garlic extracts also lower cholesterol and there is evidence that DATS can alter the expression of genes and inhibit enzymes that are relevant to cholesterol synthesis.
Chemische Eigenschaften
Diallyl trisulfide is a yellow liquid with a disagreeable odor. It is a stable transformation product of allicin. Insoluble in water and ethanol, miscible in ether. Natural products are found in onions, garlic, etc. Diallyl trisulfide (DATS) and diallyl disulfide (DADS) are the two major organosulfides in garlic oil.
Occurrence
Reported found in garlic oil.
Verwenden
Diallyl trisulfide (DATS) has been used to study its antimicrobial effects against Campylobacter jejuni. It has also been used to test its effect on hepatic regeneration in partial hepatectomy (PHx) rats.
Verwenden
Diallyl Trisulfide, is an organosulfur garlic compound that induces neovasculogenesis and has preventive effects against ischemic injuries. Antiarrythmic effect.
synthetische
In nature, diallyl trisulfide is formed from alliin and allicin.
Definition
ChEBI: Diallyl trisulfide is an organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity It has a role as an apoptosis inducer, an estrogen receptor antagonist, an antineoplastic agent, a vasodilator agent, an antioxidant, an anti-inflammatory agent, an insecticide, an antiprotozoal drug, a platelet aggregation inhibitor and an antilipemic drug.
Allgemeine Beschreibung
Diallyl trisulfide (DATS) is one of the organosulfur compounds found in garlic (Allium sativum), and other Allium genera such as onions. This sulfur-rich compound is produced by the rapid disintegration of its metabolic precursor Allicin.
Biochem/physiol Actions
DATS is a potent anti-cancer and chemopreventive agent that regulates apoptosis, metastasis, cell cycle, and angiogenesis in cancer pathways. It is also an excellent neuroprotective agent. DATS elicits antioxidant and anti-inflammatory activities against doxorubicin (DOX)-induced rats brains. It may improve glycemic control, muscle glucose utilization, and insulin secretion in streptozotocin-induced diabetic rats.

Diallyltrisulfid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2050-87-5, Diallyl trisulfide Verwandte Suche:

Send Inquriy