1,3,8-Trihydroxy-6-methylanthrachinon

Bezeichnung:1,3,8-Trihydroxy-6-methylanthrachinon

CAS-Nr518-82-1

Englisch Name:Emodin

CBNumberCB2258856

SummenformelC15H10O5

Molgewicht270.24

MOL-Datei518-82-1.mol

Synonyma

1,3,8-Trihydroxy-6-methylanthrachinon

1,3,8-Trihydroxy-6-methylanthrachinon physikalisch-chemischer Eigenschaften

Schmelzpunkt	255 °C (dec.)(lit.)
Siedepunkt	373.35°C (rough estimate)
Dichte	1.3280 (rough estimate)
Brechungsindex	1.5000 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble
Aggregatzustand	powder
pka	6.39±0.20(Predicted)
Farbe	orange
Wasserlöslichkeit	<0.1 g/100 mL at 19 ºC
Merck	14,3561
BRN	1888141
InChIKey	RHMXXJGYXNZAPX-UHFFFAOYSA-N
LogP	3.641 (est)
CAS Datenbank	518-82-1(CAS DataBase Reference)
EPA chemische Informationen	Emodin (518-82-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39-36/37
WGK Germany	3
RTECS-Nr.	CB7920600
F	8-10-23
HS Code	29146990
Giftige Stoffe Daten	518-82-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Emodin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
red-orange powder
Verwenden
antibacterial, antineoplastic, cathartic, tyrosine kinase inhibitor
Verwenden
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
- to inhibit Tau aggregation
- for direct binding assay
Verwenden
Occurs mostly as the rhamnoside (see Frangulin) in rhubarb root. Cathartic.
Definition
ChEBI: Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs. It has a role as a tyrosine kinase inhibitor, an antineoplastic agent, a laxative and a plant metabolite. It is functionally related to an emodin anthrone. It is a conjugate acid of an emodin(1-).
Allgemeine Beschreibung
Orange needles or powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Emodin may be sensitive to prolonged exposure to light. Probably a weak acid due to the phenolic functional groups.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Emodin emits acrid smoke and irritating fumes.
Brandgefahr
Flash point data for Emodin are not available; however, Emodin is probably combustible.
Biologische Aktivität
Naturally occurring anthraquinone that displays a range of biological activities. Exhibits anti-inflammatory, antitumor and neuroprotective effects.
Biochem/physiol Actions
Cell permeable: yes
läuterung methode
Archin forms orange needles from EtOH, Et2O, *C6H6, toluene or pyridine. It sublimes above 200o at 12mm. [Tutin & Clewer J Chem Soc 99 946 1911, IR: Bloom et al. J Chem Soc 178 1959, UV: Birkinshaw Biochem J 59 495 1955, Raistrick Biochem J 34 159 1940.] 1R,2S-(-)Ephedrine see (-)-ephedrine (1R,2S-2-methylamino-1-phenylpropanol) in “Miscellaneous” in Chapter 6.

Emodin Upstream-Materialien And Downstream Produkte

1,3,8-Trihydroxy-6-methylanthrachinon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

518-82-1, Emodin Verwandte Suche:

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