Proxymetacainhydrochlorid

Bezeichnung:Proxymetacainhydrochlorid

CAS-Nr5875-06-9

Englisch Name:Proparacaine hydrochloride

CBNumberCB2242028

SummenformelC16H27ClN2O3

Molgewicht330.85

MOL-Datei5875-06-9.mol

Synonyma

Proxymetacainhydrochlorid

Proxymetacainhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	182.0-183.3°
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Chloroform (Slightly), Methanol, Water
Aggregatzustand	Solid
pka	3.2(at 25℃)
Farbe	White to Off-White
maximale Wellenlänge (λmax)	300nm(MeOH)(lit.)
Merck	14,7807
InChI	InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H
InChIKey	BFUUJUGQJUTPAF-UHFFFAOYSA-N
SMILES	C(OCCN(CC)CC)(=O)C1=CC=C(OCCC)C(N)=C1.[H]Cl
CAS Datenbank	5875-06-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36-43
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	DG3065000
HS Code	2922504500

Gefahreninformationscode (GHS)

Proparacaine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36:Reizt die Augen.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
Verwenden
Topical anesthetic (ophthalmic); Neuronal conductance inhibitor.
Trademarks
Alcaine (Alcon); Ophthetic (Allergan); Paracaine (Optopics).
Clinical Use
Proparacaine Hydrochloride Ophthalmic Solution is indicated for topical anesthesia in ophthalmic practice.
Nebenwirkungen
Occasional temporary stinging, burning and conjunctival redness may occur with the use of proparacaine. A rare, severe, immediate-type, apparently hyperallergic corneal reaction characterized by acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and sometimes iritis with descemetitis has been reported. Allergic contact dermatitis from proparacaine with drying and fissuring of the fingertips has been reported.
Mode of action
The mechanism of action of proparacaine hydrochloride is to reduce the instantaneous permeability of neurons to sodium, stabilize the nerve cell membrane, and prevent the generation and conduction of nerve electrical impulses, thereby producing anesthesia.Likely inhibits epithelial voltage gated sodium channels like other local anesthetics.
Einzelnachweise
1. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. DOI:10.1016/j.jpba.2020.113497
2. https://pi.bausch.com/globalassets/pdf/PackageInserts/Pharma/Rx-Generics/Proparacaine-HCl-Ophthalmic-Solution.pdf
3. Imming P., Sinning C., Meyer A. Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct; 5(10):821-34. DOI:10.1038/nrd2132
4. T., Levent T., Inci M.A. Toxic keratopathy associated with abuse of topical anesthetics and amniotic membrane transplantation for treatment. Int J Ophthalmol. 2015; 8(5): 938–944. DOI:10.3980/j.issn.2222-3959.2015.05.15
5. Proparacaine Hydrochloride Topical Drop and Intracameral 0.5% Lignocaine for Phacotrabeculectomy in Patients with Primary Open Angle Glaucoma DOI:10.4103/0974-9233.134669
6. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=447a2a64-0507-4fe8-bb44-cc36c3916151&type=display

Proxymetacainhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5875-06-9, Proparacaine hydrochloride Verwandte Suche:

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