Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone

Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1

• Verwenden

  Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.

• Einzelnachweise

  [1] LYNNIE TRZOSS. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 41: 14687-14692. DOI:10.1073/pnas.1410932111

Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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