Fumonisin B2

Bezeichnung:Fumonisin B2

CAS-Nr116355-84-1

Englisch Name:Fumonisin B2

CBNumberCB2173535

SummenformelC34H59NO14

Molgewicht705.83

MOL-Datei116355-84-1.mol

Fumonisin B2 physikalisch-chemischer Eigenschaften

Schmelzpunkt	<3200(dec)
Siedepunkt	705.92°C (rough estimate)
Dichte	1.2044 (rough estimate)
Brechungsindex	1.6630 (estimate)
Flammpunkt	6 °C
storage temp.	-20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	3?+-.0.23(Predicted)
Aggregatzustand	Off-white solid
Farbe	Off-White to Beige
Stabilität	Hygroscopic
CAS Datenbank	116355-84-1

Sicherheit

Kennzeichnung gefährlicher	T+,T,Xn,F
R-Sätze:	26/27/28-36/37/38-40-36-20/21/22-11
S-Sätze:	22-36/37/39-45-36/37-16-26
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS-Nr.	TZ8335000
HS Code	29221990

Gefahreninformationscode (GHS)

Fumonisin B2 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R36:Reizt die Augen.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Fumonisin B2 belongs to the family of toxins known as fumonisins. It is produced by several species of Fusarium molds primarily by Fusarium verticillioide. It is one of the major mycotoxin contaminant in corn and corn-based foods. Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than the latter and it inhibits sphinganine-N-acetyltransferase (ceramide synthase).
Fumonisin B2 is a carcinogenic mycotoxin generally present on corn based food and feed-stuff, which is produced by the fungus Fusarium verticillioides and Fusarium moniliforme. Fumonisin B2 can also be detected in the industrially important fungi, Aspergillus niger.
Chemische Eigenschaften
Pale Yellow Crystalline Solid
Verwenden
A mycotoxin produced by mold associated with corn. Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.
Verwenden
Fumonisin B2 is a minor analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. To date much of the research on the pharmacology of the fumonisins has focused on fumonisin B1. It is generally accepted that fumonisin B2 acts on ceramide biosynthesis, however, the pharmacology of the minor analogues is less well explored.
Verwenden
Contact herbicide used also to produce desiccation and defoliation
Definition
ChEBI: Fumonisin B2 is a fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). It has a role as an Aspergillus metabolite and a carcinogenic agent. It is a fumonisin, a primary amino compound, a diol and a diester.
Allgemeine Beschreibung
Fumonisin B₂ (FB₂) is a diester of tricarballylic acid and polyhydric alcohols.. Fumonisins B₂ (FB₂) does not have one or more hydroxyl groups at the C5 or C10 positions.
Biochem/physiol Actions
Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.
Sicherheitsprofil
Fumonisin B2, a mycotoxin produced by Fusariummoniliforme in a variety of cereals, is a potent inhibitor of sphingosine N-acyltransferase (ceramidesynthase), blocking sphingolipid de novo synthesis. Fumonisin (FB) is a mycotoxin, a structurally similar bidentate compound composed of different polyhydric alcohols and propionic tricarboxylic acids, of which fumonisin B1 (FB1), fumonisin B2 (FB2) and fumonisin B3 (FB3) are the main components of contaminated food and its products, and a potential trigger for cancer, and has been declared by the International Agency for Research on Cancer as The International Agency for Research on Cancer has declared fumonisins as "Class 2B" toxicants (possible carcinogens to humans).

Fumonisin B2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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