Tenoxicam

Bezeichnung:Tenoxicam

CAS-Nr59804-37-4

Englisch Name:Tenoxicam

CBNumberCB2163299

SummenformelC13H11N3O4S2

Molgewicht337.37

MOL-Datei59804-37-4.mol

Tenoxicam physikalisch-chemischer Eigenschaften

Schmelzpunkt	209-2130C (dec)
Dichte	1.4737 (rough estimate)
Brechungsindex	1.6390 (estimate)
storage temp.	2-8°C
Löslichkeit	Practically insoluble in water, sparingly soluble in methylene chloride, very slightly soluble in anhydrous ethanol. It dissolves in solutions of acids and alkalis.
pka	pKa1 5.3, pKa2 1.1(at 25℃)
Aggregatzustand	Solid
Farbe	White to Yellow to Green
Wasserlöslichkeit	61.9mg/L(32 ºC)
CAS Datenbank	59804-37-4

Sicherheit

Kennzeichnung gefährlicher	T,Xi
R-Sätze:	23/24/25-36/37/38
S-Sätze:	36/37/39-45-36-26-36/37
RIDADR	UN 2811 6.1/PG 3
WGK Germany	2
RTECS-Nr.	XJ9095060
HS Code	2934.99.3000
HazardClass	6.1

Gefahreninformationscode (GHS)

Tenoxicam Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Tenoxicam is a non-steroidal antiinflammatory agent with a profile similar to related piroxicam and now withdrawn isoxicam (55). It is useful in the treatment of rheumatoid arthritis, osteoarthritis and related disorders.
Chemische Eigenschaften
Yellow Crystalline Powder
Originator
Hoffmann-La Roche (Switzerland)
Verwenden
Tenoxicam has been used:
    as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
    as a standard in microanalysis of NSAIDs by spectrophotometry
    to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers
Definition
ChEBI: Tenoxicam is a thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a heteroaryl hydroxy compound, a monocarboxylic acid amide, a member of pyridines and a thienothiazine.
Trademarks
Tilcotil
Biochem/physiol Actions
Tenoxicam (TX) possesses antipyretic?and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.
Clinical Use
NSAID and analgesic
Synthese
The reaction of methyl 3-hydroxythiophene- 2-carboxylate with PCl5 in refluxing CCl4 gives 3-chlorothiophene-2-carboxylic acid, which by treatment with NaHSO3 and Cu in aqueous alkaline solution at 143 ?C in a pressure vessel is converted into 3- sulfothiophene-2-carboxylic acid. Its esterification with refluxing methanol affords methyl- 3-sulfothiophene-2-carboxylate, which by reaction with refluxing SOCl2 yields methyl- 3-chlorosulfonylthiophene-2-carboxylate. The following condensation with sarcosine ethyl ester in hot CHCl3 gives 3-(N-ethoxycarbonylmethyl- N-methylsulfamoyl)thiophene-2-carboxylate, which is cyclized by treatment with sodium methoxide in refluxing methanol affording 3-ethoxycarbonyl-4-hydroxy-2-methyl-2Hthieno--1,2-thiazine 1,1-dioxide. Finally this compound is condensed with 2-aminopyridine in refluxing toluene
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.
Stoffwechsel
Metabolised in the liver via cytochrome P450 2C9 to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).
Metabolites are excreted mainly in the urine; there is some biliary excretion of glucuronide conjugates of the metabolites.

Tenoxicam Upstream-Materialien And Downstream Produkte

Tenoxicam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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