(S)-(+)-3-Hydroxytetrahydrofuran

Bezeichnung:(S)-(+)-3-Hydroxytetrahydrofuran

CAS-Nr86087-23-2

Englisch Name:(S)-(+)-3-Hydroxytetrahydrofuran

CBNumberCB2142463

SummenformelC4H8O2

Molgewicht88.11

MOL-Datei86087-23-2.mol

(S)-(+)-3-Hydroxytetrahydrofuran physikalisch-chemischer Eigenschaften

alpha	18.5 º (c=2 MeOH)
Siedepunkt	80 °C/15 mmHg (lit.)
Dichte	1.103 g/mL at 25 °C (lit.)
Dampfdruck	47Pa at 25℃
Brechungsindex	n20/D 1.45(lit.)
Flammpunkt	175 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform, Methanol (Slightly)
pka	14.49±0.20(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless to pale yellow
Wichte	1.11
Optische Aktivität	[α]20/D +17.5°, c = 2.4 in methanol
Wasserlöslichkeit	soluble
BRN	4652609
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey	XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP	-0.784 at 22℃ and pH6.8
Oberflächenspannung	72mN/m at 1g/L and 25℃
CAS Datenbank	86087-23-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
RIDADR	NA 1993 / PGIII
WGK Germany	3
HS Code	29321900

Gefahreninformationscode (GHS)

(S)-(+)-3-Hydroxytetrahydrofuran Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
Chemische Eigenschaften
Colourless Liquid
Verwenden
(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
Verwenden
(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
Synthese
(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.

(S)-(+)-3-Hydroxytetrahydrofuran Upstream-Materialien And Downstream Produkte

(S)-(+)-3-Hydroxytetrahydrofuran Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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