1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Bezeichnung:1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

CAS-Nr6001-64-5

Englisch Name:1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

CBNumberCB2134363

SummenformelC8H16Cl6O3

Molgewicht372.93

MOL-Datei6001-64-5.mol

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	77-79 °C(lit.)
Siedepunkt	173-175 °C
Flammpunkt	100 °C
storage temp.	2-8°C
Löslichkeit	Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
Aggregatzustand	Crystalline Powder, Crystals and/or Chunks
Farbe	White to almost white
Wasserlöslichkeit	Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water.
Merck	14,2129
BRN	878167
Stabilität	Stable. Generates toxic fumes on combustion. Incompatible with strong oxidizing agents.
LogP	2.074 (est)
CAS Datenbank	6001-64-5

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36/37/39
WGK Germany	3
RTECS-Nr.	UC0175000
TSCA	Yes
HS Code	29055900

Gefahreninformationscode (GHS)

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white crystalline solid
Verwenden
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.
Verwenden
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate in combination with dimethyl sulfone, can serve as an appropriate solvent for the freeze drying of certain parenteral organic drugs, which have an increase in many factors such as stability, dissolution rate, dosing accuracy and sterility.
Verwenden
Pharmaceutic aid (antimicrobial agent).
Trademarks
Chloretone (Parke-Davis).
Allgemeine Beschreibung
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) converts benzisoxazole to α-aryloxyisobutyric acid. 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.
Biochem/physiol Actions
Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Upstream-Materialien And Downstream Produkte

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6001-64-5, 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Verwandte Suche:

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