Honokiol

Bezeichnung:Honokiol

CAS-Nr35354-74-6

Englisch Name:Honokiol

CBNumberCB2111629

SummenformelC18H18O2

Molgewicht266.33

MOL-Datei35354-74-6.mol

Honokiol physikalisch-chemischer Eigenschaften

Schmelzpunkt	86℃
Siedepunkt	400.1±40.0 °C(Predicted)
Dichte	1.107±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: 36 mg/mL
Aggregatzustand	powder
pka	9.89±0.48(Predicted)
Farbe	White to Off-White
Merck	14,4742
Stabilität	Light Sensitive
InChIKey	FVYXIJYOAGAUQK-UHFFFAOYSA-N
LogP	4.200 (est)
CAS Datenbank	35354-74-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	41-51/53
S-Sätze:	26-39-61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
HazardClass	9
HS Code	29072990

Gefahreninformationscode (GHS)

Honokiol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R41:Gefahr ernster Augenschäden.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Magnolol is derived from the root bark and branch bark of magnolia or Magnolia officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po) is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang, Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places. Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better quality, while in Zhejiang, it is called “warm park,” with a larger output.
Physikalische Eigenschaften
Appearance: white fine powder. Solubility: practically insoluble in water; very soluble in benzene, ethyl ether, chloroform, and acetone. Melting point: magnolol is 102 °C. Honokiol is 87.5 °C.
History
In 1930, magnolol was first isolated from the bark of Cortex magnoliae officinalis in China by Japanese Sugii, and it was also isolated from Cortex magnoliae officinalis in Japan. In 1973, magnolol and its isomers honokiol were isolated from Cortex magnoliae officinalis in China and Japan by Japanese Fujita.
The drug research and development of magnolol and honokiol remain in pharmacological activity and preclinical research. Kyung Hee University from Korea declared a preclinical study in 2003, in which allergy, anxiety, angina, and heart failure are indications for honokiol.
Verwenden
Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.
Verwenden
Honokiol has been used:
- to study its effects on plasmid hSirt3^102-399 deacetylation activity
- as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
- to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
- for intracerebroventricular (ICV) cannulation
Indications
These compounds are recorded in the British Pharmacopoeia (2017) and European Pharmacopoeia (8.7th ed.). They are mainly used as antibacterial and antifungal agents.
Definition
ChEBI: Honokiol is a member of biphenyls.
Allgemeine Beschreibung
Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.
Biochem/physiol Actions
Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.
Pharmakologie
Magnolol and honokiol have the pharmacological effects of prolonging central muscle relaxation, inhibition of the central nervous, anti-inflammatory, antibacterial, antimicrobial, antiulcer, antioxidant, antitumor, hormone regulation, and antidiabetes .
Lager
+4°C

Honokiol Upstream-Materialien And Downstream Produkte

Honokiol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

35354-74-6, Honokiol Verwandte Suche:

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