5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.

• Verwenden

  DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).

• Biologische Aktivität

  A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

• Einzelnachweise

  1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627

5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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