Nigericin sodium salt

Bezeichnung:Nigericin sodium salt

CAS-Nr28643-80-3

Englisch Name:Nigericin sodium salt

CBNumberCB1972391

SummenformelC40H69NaO11

Molgewicht748.97

MOL-Datei28643-80-3.mol

Nigericin sodium salt physikalisch-chemischer Eigenschaften

Schmelzpunkt	approximate 255℃
storage temp.	2-8°C
Löslichkeit	Soluble in chloroform, methanol or ethanol
Aggregatzustand	solution
Farbe	White
Merck	13,6569
BRN	3892398
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey	MOYOTUKECQMGHE-NTQCAYBPSA-M
LogP	4.817 (est)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38
S-Sätze:	26-36/37/39-45
RIDADR	UN 3462 6.1/PG 3
WGK Germany	3
RTECS-Nr.	QT6840000
HazardClass	6.1
HS Code	29419090

Gefahreninformationscode (GHS)

Nigericin sodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Nigericin Na (28643-80-3) is a polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Induces apoptosis resulting from intracellular acidification. Ion selectivity for nigericin Na is K+> Rb+> Cs+>>Na+. Cell permeable.
Chemische Eigenschaften
NIGERICIN SODIUM SALT is white powder
Verwenden
Nigericin sodium is a salt of the atypical polyether antibiotic, nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.
Verwenden
Nigericin sodium is the atypical salt of nigericin. Since nigericin is an ionophore, its very high affinity for monovalent cations such as Na+ and K+ means that formation of a salt is a facile possess occurring during purification under any but highly acidic conditions. Typically, the salts of polyether ionophores like the free acid, are readily extracted into organic solvents. The sodium ion is stabilised within a polar pocket of the structure, effectively making the salt and free acid different chemical moieties with the potential for differing pharmacology, a fact not readily appreciated in the literature.
Verwenden
Nigericin sodium salt is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). It disrupts membrane potential and stimulates ATPase activity in mitochondria. It transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na. It kills bacteria by facilitating the diffusion of ions across membranes. It is widely used in studies of the consequences of changes in membrane potential in variable systems.
Allgemeine Beschreibung
A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H⁺ (antiport). Transports monovalent cations across membranes with the following specificities: K⁺>Rb⁺>Cs⁺>>Na⁺. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
Biochem/physiol Actions
Product does not compete with ATP.
Lager
Store at -20°C
Einzelnachweise
1) Akhmedov et al. (2010), Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells; FASEB J., 24 4613 2) Gong et al. (2010), Chemical probing reveals insights into the signaling mechanism of inflammasome activation; Cell Res., 20 1289

Nigericin sodium salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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