2-Thenoesure

Bezeichnung:2-Thenoesure

CAS-Nr527-72-0

Englisch Name:2-Thiophenecarboxylic acid

CBNumberCB1778926

SummenformelC5H4O2S

Molgewicht128.15

MOL-Datei527-72-0.mol

Synonyma

2-Thenoesure

2-Thenoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	125-127 °C(lit.)
Siedepunkt	260 °C(lit.)
Dichte	1.42
Brechungsindex	1.5160 (estimate)
Flammpunkt	259-261°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Acetone (Slightly), Chloroform (Slightly)
Aggregatzustand	solid
pka	3.49(at 25℃)
Farbe	White to Off-White
Wasserlöslichkeit	80 g/L (20 ºC)
Merck	14,9354
BRN	110150
InChIKey	QERYCTSHXKAMIS-UHFFFAOYSA-N
LogP	1.570
CAS Datenbank	527-72-0(CAS DataBase Reference)
NIST chemische Informationen	2-Thiophenecarboxylic acid(527-72-0)
EPA chemische Informationen	2-Thiophenecarboxylic acid (527-72-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	XM8330200
Hazard Note	Irritant
TSCA	Yes
HS Code	29349990

Gefahreninformationscode (GHS)

2-Thiophenecarboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.
Verwenden
2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Application
The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.
Vorbereitung Methode
Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.
Definition
ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
läuterung methode
Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]

2-Thiophenecarboxylic acid Upstream-Materialien And Downstream Produkte

2-Thenoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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