4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

Bezeichnung:4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

CAS-Nr30827-99-7

Englisch Name:4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

CBNumberCB1769137

SummenformelC8H11ClFNO2S

Molgewicht239.69

MOL-Datei30827-99-7.mol

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	175-177 °C
storage temp.	2-8°C
Löslichkeit	H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
Aggregatzustand	Powder
Farbe	White
PH	pH3.0～5.0 (10g/L, 25℃)
Wasserlöslichkeit	10 g/L (20 ºC)
Sensitive	Moisture Sensitive
BRN	7604627
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChIKey	WRDABNWSWOHGMS-UHFFFAOYSA-N
CAS Datenbank	30827-99-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	C,Xi
R-Sätze:	34-36/37/38
S-Sätze:	45-36/37/39-26-36
RIDADR	UN 3261
WGK Germany	3
Hazard Note	Corrosive
HazardClass	8
PackingGroup	II
HS Code	29214990

Gefahreninformationscode (GHS)

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
Chemische Eigenschaften
white powder
Verwenden
Recommended concentrations for use are 0.1-1 mM.
Verwenden
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Allgemeine Beschreibung
Pefabloc^? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.
Lager
Store at -20°C
Einzelnachweise
1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

30827-99-7, 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Verwandte Suche:

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