NS-398

Bezeichnung:NS-398

CAS-Nr123653-11-2

Englisch Name:NS-398

CBNumberCB1754593

SummenformelC13H18N2O5S

Molgewicht314.36

MOL-Datei123653-11-2.mol

NS-398 physikalisch-chemischer Eigenschaften

Schmelzpunkt	124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Siedepunkt	490.6±55.0 °C(Predicted)
Dichte	1.377±0.06 g/cm3(Predicted)
RTECS-Nr.	PB0473500
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: >5 mg/mL
Aggregatzustand	solid
pka	6.33±0.10(Predicted)
Farbe	off-white

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
HS Code	2935.90.9500

NS-398 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.
Verwenden
NS-398 is a selective Cox-2 inhibitor neuroprotective agent.
Definition
ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Biologische Aktivität
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
Lager
Store at RT
Einzelnachweise
[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Upstream-Materialien And Downstream Produkte

NS-398 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

123653-11-2, NS-398 Verwandte Suche:

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