3-Hydroxy-5-methylisoxazol

Bezeichnung:3-Hydroxy-5-methylisoxazol

CAS-Nr10004-44-1

Englisch Name:Hymexazol

CBNumberCB1754230

SummenformelC4H5NO2

Molgewicht99.09

MOL-Datei10004-44-1.mol

Synonyma

3-Hydroxy-5-methylisoxazol

3-Hydroxy-5-methylisoxazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	80°C
Siedepunkt	185.54°C (rough estimate)
Dichte	1.2992 (rough estimate)
Dampfdruck	0.182 Pa (25 °C)
Brechungsindex	1.4170 (estimate)
storage temp.	2-8°C
Löslichkeit	Soluble in alcohol, acetone, THF, chloroform
Aggregatzustand	Powder
pka	5.91 (weak acid)
Wasserlöslichkeit	65,100 mg l^-1 (20 °C)
Farbe	White to Orange
Sensitive	Light Sensitive
Merck	14,4856
InChIKey	KGVPNLBXJKTABS-UHFFFAOYSA-N
CAS Datenbank	10004-44-1(CAS DataBase Reference)
EPA chemische Informationen	Hymexazol (10004-44-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-41-52/53
S-Sätze:	26-39-61
WGK Germany	3
RTECS-Nr.	NY2932000
HS Code	29349990
Toxizität	LD50 in male, female mice, rats (mg/kg): 2148, 1968, 4678, 3909 orally; 1297, 1167, 1924, 1884 s.c.; 445, 514, >1000, >1000 i.v.; in rats, rabbits (mg/kg): >10000, >2000 dermally (Nakamura, 1978)

Gefahreninformationscode (GHS)

Hymexazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R41:Gefahr ernster Augenschäden.
R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Chemische Eigenschaften
White Solid
Verwenden
Agricultural fungicide and plant growth regulator.
Verwenden
Hymexazol is used to control soil-borne diseases caused by Fusarium, Aphanomyces, Pythium, Corficium and Typhula spp. in rice, sugar beet, fodder beet, vegetables, cucurbits, ornamentals, carnations and forest tree seedlings. It is also used as a seed dressing and stimulates some plant growth.
Verwenden
Pesticide.
Definition
ChEBI: A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 4307, 1983 DOI: 10.1021/jo00171a030
Stoffwechselwegen
Degradation of hymexazol in soil gave acetoacetamide and the product of rearrangement, 5-methyl-2(³H)-oxazolone.H owever, in plants the fungicide was principally converted into its O- and N-glucoside conjugates in the roots and shoots. The two main metabolites of hymexazol found in the urine of rats were the O-glucuronide and sulfate conjugates.
Degradation
Hymexazol is stable under alkaline conditions and relatively stable in acidic conditions. It is stable to sunlight and heat (PM). It should be noted that the parent molecule is tautomeric. Hymexazol is highly volatile and will be lost by volatilisation unless it is covered or incorporated into soil. The fungicide was completely biodegraded in natural water at 30 °C in 2 weeks and at 10-13 °C in 2 months (Rebenok and Kolesnikova, 1983). Hymexazol is stable in sunlight but it is readily degraded by ultraviolet light. Photolysis of an aqueous solution of the fungicide at 253.7 nm, using a low pressure Hg lamp, afforded the oxazolinone (2) as the major product and at least two unidentified minor components. The oxazolinone (2) has been found in soil studies as described below and is a product of rearrangement formed via an aziridinone intermediate as shown in Scheme 1 (Nakagawa et al., 1974).

Hymexazol Upstream-Materialien And Downstream Produkte

3-Hydroxy-5-methylisoxazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

10004-44-1, Hymexazol Verwandte Suche:

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