5-Amino-2-nitrobenzoesure

Bezeichnung:5-Amino-2-nitrobenzoesure

CAS-Nr13280-60-9

Englisch Name:5-Amino-2-nitrobenzoic acid

CBNumberCB1738500

SummenformelC7H6N2O4

Molgewicht182.13

MOL-Datei13280-60-9.mol

Synonyma

5-Amino-2-nitrobenzoesure

5-Amino-2-nitrobenzoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	236-238 °C (lit.)
Siedepunkt	481.3±35.0 °C(Predicted)
Dichte	1.568±0.06 g/cm3(Predicted)
Dampfdruck	0-0Pa at 20-50℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	DMSO, Methanol
pka	2.28±0.25(Predicted)
Aggregatzustand	Solid
Farbe	Yellow-Brown
Wasserlöslichkeit	Insoluble
BRN	2107512
InChIKey	KZZWQCKYLNIOBT-UHFFFAOYSA-N
LogP	-1.48 at pH7
Oberflächenspannung	70.53mN/m at 1g/L and 20℃
CAS Datenbank	13280-60-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	36/37/38-22-20/21/22
S-Sätze:	26-36/37/39-37/39-36
WGK Germany	3
HS Code	29224999

Gefahreninformationscode (GHS)

5-Amino-2-nitrobenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
5-Amino-2-nitrobenzoic acid is a reagent used in preparation of polymer-bound diazonium salts and insulin receptor tyrosine kinase activator. It is also used in 2-component dendritic chain reactions and activation of hydrophobic dendrimers.
Chemische Eigenschaften
5-Amino-2-nitrobenzoic acid appears as a yellow powder or crystal. Its crystal structure is: the 5-amino-2-nitrobenzoic acid crystallizes in the monoclinic P21/c space group with a = 3.898(2)?, b = 13.531(3)?, c = 14.301(3) ?, and β = 90.83(3)?. The adjacent molecules form a cyclic dimmer by intermolecular hydrogen bonds of type O H···O with their carboxyl groups. In the crystal structure NH2 group forms a threecenter hydrogen bond with oxygen atoms of NO2 group.
Verwenden
5-Amino-2-nitrobenzoic acid can be used as a standard for the determination of γ-GT activity using 5-amino-2-nitrobenzoic acid as a standard. 5-Amino-2-nitrobenzoic acid (ANB) can also be used for spectroscopic studies by determining the FTIR and FT-Raman spectra of ANB in the 400-4000 cm-1 range and calculating the theoretically constructed spectra in good agreement with the experimental spectra.
Verwenden
Reactant for:
- Two-component dendritic chain reactions
- Enzymic activation of hydrophobic self-immolative dendrimers
- Preparation of insulin receptor tyrosine kinase activator
- Preparation of polymer-bound diazonium salts using Merrifield resin-bound piperazine
Application
5-Amino-2-nitrobenzoic acid is a drug that has been shown to inhibit the activity of proteases. It has been used to detect the presence of protease activity in urine samples, as well as to study the inhibition of protease activity by other drugs. It is an inhibitor of chymotrypsin, trypsin, and elastase. This drug has been shown to be effective in inhibiting these enzymes at low concentrations, with a detection sensitivity of approximately 0.1 μM. It inhibits the growth of bacteria by binding to them and preventing protein synthesis. The compound also inhibits the enzyme dihydrolipoamide dehydrogenase in mitochondria, which is required for cellular respiration and energy production.
läuterung methode
Crystallise the acid from water. [Beilstein 14 III 1021.]

5-Amino-2-nitrobenzoic acid Upstream-Materialien And Downstream Produkte

5-Amino-2-nitrobenzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13280-60-9, 5-Amino-2-nitrobenzoic acid Verwandte Suche:

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