AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Biologische Aktivität

  Ac-RYYRIK-NH2 is a potent ORL1 partial agonist as an endogenous ligand of ORL1 in CHO cells (Kd=1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist of G protein activation and competitively antagonizes noc/OFQ-stimulated [35S]-GTPgS-binding G protein in rat meninges and brain sections.

• in vivo

  Ac-RYYRIK-NH2 (intracerebroventricularly (icv) inhibits spontaneous locomotor activity in mice with an ID ₅₀ of 0.07 nmol. Co-administration of noc/OFQ and Ac-RYYRIK-NH2

• target

  Kd: 1.5 nM (ORL1 transfected in CHO cells)

AC-ARG-TYR-TYR-ARG-ILE-LYS-NH2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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