HYPOPHYLLANTHIN

Bezeichnung:HYPOPHYLLANTHIN

CAS-Nr33676-00-5

Englisch Name:HYPOPHYLLANTHIN

CBNumberCB1716924

SummenformelC24H30O7

Molgewicht430.49

MOL-Datei33676-00-5.mol

HYPOPHYLLANTHIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	129-130℃
Siedepunkt	511.1±50.0 °C(Predicted)
Dichte	1.158
storage temp.	4°C, protect from light
Löslichkeit	≤0.2mg/ml in ethanol;10mg/ml in DMSO;30mg/ml in dimethyl formamide
Aggregatzustand	crystalline solid
Farbe	White to off-white
LogP	3.770 (est)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22

Gefahreninformationscode (GHS)

HYPOPHYLLANTHIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity. In Caco-2 cells 100 μM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.
Verwenden
Hypophyllanthin can be used to study the modulation of NSAID-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants.
in vitro
previous study found that hypophyllanthin could inhibit p-gp function with comparable potencies, but could not affect mrp2 activity. when hypophyllanthin was washed out before addition of substrate, the inhibitory action against p-gp function was lost. these results indicated the reversibility of the inhibition. moreover, prolonged exposure of the caco-2 cells to hypophyllanthin up to 7 days had no effect on p-gp function [1].
in vivo
a previous study was conducted to evaluate the effect of carbofuran on estrous cycle and follicular growth in virgin wister rats as well as recovering from the damaged estrous cycle with treatment of hypophyllanthin. hypophyllanthin is non-steroidal plant molecule with estrogen-like activities, but with an estrogen-type activity. hypophyllanthin was capable of interacting with estrogen receptors, showing both agonist and antagonist methods of action. therefore, hypophyllanthin was found to be systemically transformed into enterolignan, which is known to be responsible for augmenting estrus cycle in rats [2].
Einzelnachweise
[1] n. sukhaphirom, n. vardhanabhuti, h. chirdchupunseree, et al. phyllanthin and hypophyllanthin inhibit function of p-gp but not mrp2 in caco-2 cells. journal of pharmacy and pharmacology 65, 292-299 (2012).
[2] aminul islam et al. estrogenic properties of phyllanthin and hypophyllanthin from phyllanthus amarus against carbofuran induced toxicity in female rats. pharmacologyonline 3: 1006-1016 (2008).

HYPOPHYLLANTHIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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