EIPA Struktur

EIPA

Bezeichnung:EIPA

CAS-Nr1154-25-2

Englisch Name:EIPA

CBNumberCB1706411

SummenformelC11H18ClN7O

Molgewicht299.76

MOL-Datei1154-25-2.mol

EIPA physikalisch-chemischer Eigenschaften

Schmelzpunkt	202-205 °C(lit.)
Dichte	1.49±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
Löslichkeit	Acetonitrile (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
pka	8.67±0.46(Predicted)
Aggregatzustand	Off-white to yellow solid.
Farbe	Pale Yellow to Green
Stabilität	Unstable in methanol
CAS Datenbank	1154-25-2

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
RIDADR	2811
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

Gefahreninformationscode (GHS)

EIPA Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with K_i values of 0.02, 0.5, 2.4, and 0.42 μM, respectively. It less effectively inhibits NHE4 (IC₅₀ ≥10 μM). EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.
Chemische Eigenschaften
Yellow Solid
Verwenden
5-(N-Ethyl-N-isopropyl)amiloride has been used:
- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
- in Pluronic F-127 stock solution for Drosophila larval live-imaging
- in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo
Verwenden
Selective Na+/H+ antiporter inhibitor. Selectively enhances the excretion of sodium ions without causing an increase in excretion of potassium ions.
Definition
ChEBI: Ethylisopropylamiloride is a member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. It has a role as an anti-arrhythmia drug, a neuroprotective agent and a sodium channel blocker. It is a member of guanidines, an aromatic amine, an organochlorine compound, a tertiary amino compound, a member of pyrazines and a monocarboxylic acid amide. It is functionally related to an amiloride.
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
Lager
Store at +4°C

EIPA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1154-25-2, EIPA Verwandte Suche:

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