E1R

E1R Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  E1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) with cognitive enhancing effects.

• in vitro

  The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ ³ H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.

• in vivo

  E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered ip 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice .

  Animal Model:	Male ICR and Balb/c mice weighed 23-25 g
  Dosage:	0.1, 1 and 10 mg/kg
  Administration:	Administered ip 60 min before the training session
  Result:	Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.

E1R Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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